| Item type |
文献 / Documents(1) |
| 公開日 |
2021-02-10 |
| アクセス権 |
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アクセス権 |
open access |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 出版社版DOI |
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識別子タイプ |
DOI |
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|
関連識別子 |
https://doi.org/10.1371/journal.ppat.1008823 |
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言語 |
ja |
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|
関連名称 |
10.1371/journal.ppat.1008823 |
| 出版タイプ |
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|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
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|
タイトル |
Prion protein signaling induces M2 macrophage polarization and protects from lethal influenza infection in mice |
|
言語 |
en |
| タイトル別表記 |
|
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その他のタイトル |
PrP in M2 macrophages and influenza |
|
言語 |
en |
| 著者 |
千田, 淳司
原, 英之
内山, 圭司
高橋, 悦久
ミヤタ, ヒロノリ
小迫, 英尊
トミオカ, ユキコ
イトウ, トシヒロ
ホリウチ, ヒロユキ
マツダ, ハルオ
木戸, 博
坂口, 末廣
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| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
The cellular prion protein, PrPC, is a glycosylphosphatidylinositol anchored-membrane glycoprotein expressed most abundantly in neuronal and to a lesser extent in non-neuronal cells. Its conformational conversion into the amyloidogenic isoform in neurons is a key pathogenic event in prion diseases, including Creutzfeldt-Jakob disease in humans and scrapie and bovine spongiform encephalopathy in animals. However, the normal functions of PrPC remain largely unknown, particularly in non-neuronal cells. Here we show that stimulation of PrPC with anti-PrP monoclonal antibodies (mAbs) protected mice from lethal infection with influenza A viruses (IAVs), with abundant accumulation of anti-inflammatory M2 macrophages with activated Src family kinases (SFKs) in infected lungs. A SFK inhibitor dasatinib inhibited M2 macrophage accumulation in IAV-infected lungs after treatment with anti-PrP mAbs and abolished the anti-PrP mAb-induced protective activity against lethal influenza infection in mice. We also show that stimulation of PrPC with anti-PrP mAbs induced M2 polarization in peritoneal macrophages through SFK activation in vitro and in vivo. These results indicate that PrPC could activate SFK in macrophages and induce macrophage polarization to an anti-inflammatory M2 phenotype after stimulation with anti-PrP mAbs, thereby eliciting protective activity against lethal infection with IAVs in mice after treatment with anti-PrP mAbs. These results also highlight PrPC as a novel therapeutic target for IAV infection. |
|
言語 |
en |
| 書誌情報 |
en : PLOS Pathogens
巻 16,
号 8,
p. e1008823,
発行日 2020-08-26
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| 収録物ID |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
15537366 |
| 収録物ID |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
15537374 |
| 出版者 |
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出版者 |
PLOS |
|
言語 |
en |
| 権利情報 |
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|
言語 |
en |
|
権利情報 |
© 2020 Chida et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
| EID |
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|
識別子 |
371058 |
|
識別子タイプ |
URI |
| 言語 |
|
|
言語 |
eng |
plospathog_16_8_e1008823.pdf (4.7 MB)
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