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Differences among patients with and without nonalcoholic fatty liver disease having elevated alanine aminotransferase levels at various stages of metabolic syndrome

https://tokushima-u.repo.nii.ac.jp/records/2008539
https://tokushima-u.repo.nii.ac.jp/records/2008539
8a40dcc7-8fda-4407-b86d-3b383b92f3e1
名前 / ファイル ライセンス アクション
pone_15_8_e0238388.pdf pone_15_8_e0238388.pdf (1.21 MB)
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Item type 文献 / Documents(1)
公開日 2021-02-16
アクセス権
アクセス権 open access
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
出版社版DOI
関連識別子 https://doi.org/10.1371/journal.pone.0238388
関連名称 10.1371/journal.pone.0238388
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
タイトル
タイトル Differences among patients with and without nonalcoholic fatty liver disease having elevated alanine aminotransferase levels at various stages of metabolic syndrome
タイトル別表記
その他のタイトル NAFLD with elevation of alanine aminotransferase levels at various stages of metabolic syndrome
著者 曽我部, 正弘

× 曽我部, 正弘

WEKO 677
徳島大学 教育研究者総覧 274188/profile-ja.html
e-Rad_Researcher 60732790

ja 曽我部, 正弘
ISNI

ja-Kana ソガベ, マサヒロ
en Sogabe, Masahiro
Search repository
岡久, 稔也

× 岡久, 稔也

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徳島大学 教育研究者総覧 60090/profile-ja.html
e-Rad_Researcher 60304515

ja 岡久, 稔也
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ja-Kana オカヒサ, トシヤ
en Okahisa, Toshiya
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クリハラ, タケシ

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ja-Kana クリハラ, タケシ
en Kurihara, Takeshi
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武原, 正典

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影本, 開三

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友成, 哲

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抄録
内容記述 Background
The prevalence of nonalcoholic fatty liver disease (NAFLD) in the non-obese population has increased and NAFLD is not always recognized in individuals with metabolic syndrome (MS). The risk of cirrhosis is higher in patients having NAFLD with elevated alanine aminotransferase (ALT) levels than in those having NAFLD with normal ALT levels.
Objective
To measure the differences in clinical factors associated with NAFLD having elevation of ALT among subjects with Non-MS, Pre-MS, and MS, and to measure differences in metabolites between MS subjects with and without NAFLD having elevation of ALT.
Methods
Among 7,054 persons undergoing health check-ups, we included 3,025 subjects who met the selection criteria. We measured differences in clinical factors for NAFLD having elevation of ALT among subjects with Non-MS, Pre-MS, and MS, and compared metabolites between subjects with and without NAFLD having elevation of ALT in 32 subjects with MS.
Results
The prevalence of NAFLD and NAFLD having elevation of ALT was significantly progressively greater in subjects with Non-MS, Pre-MS, and MS (p <0.001, respectively). In the Non-MS group, there were significant differences between subjects with and without NAFLD having elevation of ALT with respect to body mass index (BMI), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol, hemoglobin A1c, uric acid, aspartate aminotransferase (AST); In the Pre-MS group, there were significant differences in BMI, hypertension, AST, and gamma-glutamyl transpeptidase (GGT); In the MS group, there were significant differences in HDL-C, impaired glucose tolerance, AST, and GGT. There were significant differences in levels of metabolites of nicotinamide, inosine, and acetyl- L-carnitine between MS subjects with and without NAFLD having elevation of ALT (all p <0.05).
Conclusions
Although NAFLD having elevation of ALT is important for development of NAFLD, differences in factors associated with NAFLD having elevation of ALT at various stages of MS should be considered. Additionally, several metabolites may play roles in the identification of risk for NAFLD in individuals with MS.
書誌情報 en : PLOS ONE

巻 15, 号 8, p. e0238388, 発行日 2020-08-31
収録物ID
収録物識別子タイプ ISSN
収録物識別子 19326203
出版者
出版者 PLOS
権利情報
権利情報 © 2020 Sogabe et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
EID
識別子 370966
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言語 eng
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