| Item type |
文献 / Documents(1) |
| 公開日 |
2021-03-23 |
| アクセス権 |
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アクセス権 |
open access |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 出版社版DOI |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.1038/ncomms8484 |
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言語 |
ja |
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関連名称 |
10.1038/ncomms8484 |
| 出版タイプ |
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|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
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|
タイトル |
Thymoproteasomes produce unique peptide motifs for positive selection of CD8+ T cells |
|
言語 |
en |
| 著者 |
ササキ, カツヒロ
髙田, 健介
オオテ, ユウキ
コンドウ, ヒロユキ
ソリマチ, ヒロユキ
タナカ, ケイジ
高浜, 洋介
ムラタ, シゲオ
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| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
Positive selection in the thymus provides low-affinity T-cell receptor (TCR) engagement to support the development of potentially useful self-major histocompatibility complex class I (MHC-I)-restricted T cells. Optimal positive selection of CD8+ T cells requires cortical thymic epithelial cells that express β5t-containing thymoproteasomes (tCPs). However, how tCPs govern positive selection is unclear. Here we show that the tCPs produce unique cleavage motifs in digested peptides and in MHC-I-associated peptides. Interestingly, MHC-I-associated peptides carrying these tCP-dependent motifs are enriched with low-affinity TCR ligands that efficiently induce the positive selection of functionally competent CD8+ T cells in antigen-specific TCR-transgenic models. These results suggest that tCPs contribute to the positive selection of CD8+ T cells by preferentially producing low-affinity TCR ligand peptides. |
|
言語 |
en |
| 書誌情報 |
en : Nature Communications
巻 6,
p. 7484,
発行日 2015-06-23
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| 収録物ID |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
20411723 |
| 収録物ID |
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収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA12645905 |
| 出版者 |
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|
出版者 |
Springer Nature |
|
言語 |
en |
| 権利情報 |
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|
言語 |
en |
|
権利情報 |
This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
| EID |
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|
識別子 |
300041 |
|
識別子タイプ |
URI |
| 言語 |
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|
言語 |
eng |
ncomms_6_7484.pdf (878 KB)
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