| Item type |
文献 / Documents(1) |
| 公開日 |
2021-04-19 |
| アクセス権 |
|
|
アクセス権 |
open access |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1038/s41386-019-0506-5 |
|
|
言語 |
ja |
|
|
関連名称 |
10.1038/s41386-019-0506-5 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Genome-wide association studies identify polygenic effects for completed suicide in the Japanese population |
|
言語 |
en |
| 著者 |
オオツカ, イクオ
アキヤマ, マサト
シラカワ, オサム
オカザキ, サトシ
モモザワ, ユキヒデ
カマタニ, ヨウイチロウ
イズミ, タケシ
沼田, 周助
タカハシ, モトノリ
ボク, シュウケン
ソラ, イチロウ
ヤマモト, ケン
ウエノ, ヤスヒロ
トダ, タツシ
クボ, ミチアキ
ヒシモト, アキトヨ
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Suicide is a significant public health problem worldwide, and several Asian countries including Japan have relatively high suicide rates on a world scale. Twin, family, and adoption studies have suggested high heritability for suicide, but genetics lags behind due to difficulty in obtaining samples from individuals who died by suicide, especially in non-European populations. In this study, we carried out genome-wide association studies combining two independent datasets totaling 746 suicides and 14,049 non-suicide controls in the Japanese population. Although we identified no genome-wide significant single-nucleotide polymorphisms (SNPs), we demonstrated significant SNP-based heritability (35–48%; P < 0.001) for completed suicide by genomic restricted maximum-likelihood analysis and a shared genetic risk between two datasets (P best = 2.7 × 10−13) by polygenic risk score analysis. This study is the first genome-wide association study for suicidal behavior in an East Asian population, and our results provided the evidence of polygenic architecture underlying completed suicide. |
|
言語 |
en |
| 書誌情報 |
en : Neuropsychopharmacology
巻 44,
号 12,
p. 2119-2124,
発行日 2019-09-02
|
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0893133X |
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1740634X |
| 収録物ID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA10761483 |
| 出版者 |
|
|
出版者 |
American College of Neuropsychopharmacology |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
Springer Nature |
|
言語 |
en |
| 権利情報 |
|
|
言語 |
en |
|
権利情報 |
This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
| EID |
|
|
識別子 |
365487 |
|
識別子タイプ |
URI |
| 言語 |
|
|
言語 |
eng |
neurop_44_12_2119.pdf (951 KB)
