| Item type |
文献 / Documents(1) |
| 公開日 |
2021-07-02 |
| アクセス権 |
|
|
アクセス権 |
open access |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.3390/nu9070756 |
|
|
言語 |
ja |
|
|
関連名称 |
10.3390/nu9070756 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Effects of Consuming Xylitol on Gut Microbiota and Lipid Metabolism in Mice |
|
言語 |
en |
| 著者 |
上番増, 喬
カノウ, サキ
ヨシモト, アユミ
ナイトウ, チサト
下畑, 隆明
馬渡, 一諭
髙橋, 章
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
The sugar alcohol xylitol inhibits the growth of some bacterial species including Streptococcus mutans. It is used as a food additive to prevent caries. We previously showed that 1.5–4.0 g/kg body weight/day xylitol as part of a high-fat diet (HFD) improved lipid metabolism in rats. However, the effects of lower daily doses of dietary xylitol on gut microbiota and lipid metabolism are unclear. We examined the effect of 40 and 200 mg/kg body weight/day xylitol intake on gut microbiota and lipid metabolism in mice. Bacterial compositions were characterized by denaturing gradient gel electrophoresis and targeted real-time PCR. Luminal metabolites were determined by capillary electrophoresis electrospray ionization time-of-flight mass spectrometry. Plasma lipid parameters and glucose tolerance were examined. Dietary supplementation with low- or medium-dose xylitol (40 or 194 mg/kg body weight/day, respectively) significantly altered the fecal microbiota composition in mice. Relative to mice not fed xylitol, the addition of medium-dose xylitol to a regular and HFD in experimental mice reduced the abundance of fecal Bacteroidetes phylum and the genus Barnesiella, whereas the abundance of Firmicutes phylum and the genus Prevotella was increased in mice fed an HFD with medium-dose dietary xylitol. Body composition, hepatic and serum lipid parameters, oral glucose tolerance, and luminal metabolites were unaffected by xylitol consumption. In mice, 40 and 194 mg/kg body weight/day xylitol in the diet induced gradual changes in gut microbiota but not in lipid metabolism. |
|
言語 |
en |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
xylitol |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
triglyceride |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
cholesterol |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Streptococcus mutans |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
denaturing gradient gel electrophoresis (DGGE) |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
capillary electrophoresis–mass spectrometry (CE–MS) |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
caries |
| 書誌情報 |
en : Nutrients
巻 9,
号 7,
p. 756,
発行日 2017-07-14
|
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
20726643 |
| 出版者 |
|
|
出版者 |
MDPI |
|
言語 |
en |
| 権利情報 |
|
|
言語 |
en |
|
権利情報 |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
| EID |
|
|
識別子 |
331480 |
|
識別子タイプ |
URI |
| 言語 |
|
|
言語 |
eng |
nu_9_7_756.pdf (1.81 MB)
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