| Item type |
文献 / Documents(1) |
| 公開日 |
2021-07-09 |
| アクセス権 |
|
|
アクセス権 |
open access |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.3892/ol.2018.9837 |
|
|
言語 |
ja |
|
|
関連名称 |
10.3892/ol.2018.9837 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Expression of USP22 and the chromosomal passenger complex is an indicator of malignant progression in oral squamous cell carcinoma |
|
言語 |
en |
| タイトル別表記 |
|
|
その他のタイトル |
EXPRESSION OF USP22 AND CPC IN ORAL CANCER |
|
言語 |
en |
| 著者 |
Liu, Tian
Liu, Jing
Chen, Qiuyue
Jin, Shengjian
Mi, Sisi
Shao, Wenhua
工藤, 保誠
Zeng, Sien
Qi, Guangying
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Oral cancer is a common cancer of the head and neck. Oral squamous cell carcinoma (OSCC) represents almost 90% of the total cases of head and neck cancer. Ubiquitin‑specific protease 22 (USP22) is a deubiquitinating hydrolase, and it is highly expressed in various types of cancer, which also typically have a poor prognosis. Aurora‑B and Survivin, which belong to the chromosomal passenger complex, are also highly expressed in a number of types of cancer. In the present study, USP22 expression and its associations with Aurora‑B and Survivin, and the clinicopathological features in OSCC were explored. USP22 is highly expressed in OSCC. Overexpression of USP22 is associated with lymph node metastasis and histological grade (P<0.01). Additionally, the expression of USP22 was positively associated with Aurora‑B (P<0.01), Survivin (P<0.01), and Ki‑67 (P<0.01). Furthermore, USP22 small interfering RNA inhibited cell growth and reduced the expression levels of Aurora‑B, Survivin and Cyclin B, together with the upregulation of cyclin‑dependent kinase inhibitor 1A (p21). These data suggest that USP22, Aurora‑B and Survivin promote the OSCC development and may represent novel targets for OSCC diagnosis and treatment in the future. |
|
言語 |
en |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
oral squamous cell carcinoma |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
ubiquitin‑specific protease 22 |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
survivin |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
aurora‑B |
| 書誌情報 |
en : Oncology Letters
巻 17,
号 2,
p. 2040-2046,
発行日 2018-12-17
|
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
17921074 |
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
17921082 |
| 出版者 |
|
|
出版者 |
Spandidos Publications |
|
言語 |
en |
| 権利情報 |
|
|
言語 |
en |
|
権利情報 |
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) License. |
| EID |
|
|
識別子 |
350401 |
|
識別子タイプ |
URI |
| 言語 |
|
|
言語 |
eng |
ol_17_2_2040.pdf (1.04 MB)
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