| Item type |
文献 / Documents(1) |
| 公開日 |
2021-04-23 |
| アクセス権 |
|
|
アクセス権 |
open access |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1002/prp2.166 |
|
|
言語 |
ja |
|
|
関連名称 |
10.1002/prp2.166 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Maackiain is a novel antiallergic compound that suppresses transcriptional upregulation of the histamine H1 receptor and interleukin‐4 genes |
|
言語 |
en |
| タイトル別表記 |
|
|
その他のタイトル |
Maackiain Suppresses H1R and IL-4 Gene Transcriptions |
|
言語 |
en |
| 著者 |
水口, 博之
ナリアイ, ユウキ
カトウ, シュウヘイ
ナカノ, トモヒロ
カナヤマ, トモヨ
柏田, 良樹
根本, 尚夫
川添, 和義
高石, 喜久
北村, 嘉章
武田, 憲昭
福井, 裕行
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Kujin contains antiallergic compounds that inhibit upregulation of histamine H1 receptor (H1R) and interleukin (IL)‐4 gene expression. However, the underlying mechanism remains unknown. We sought to identify a Kujin‐derived antiallergic compound and investigate its mechanism of action. The H1R and IL‐4 mRNA levels were determined by real‐time quantitative RT‐PCR. To investigate the effects of maackiain in vivo, toluene‐2,4‐diisocyanate (TDI)‐sensitized rats were used as a nasal hypersensitivity animal model. We identified (−)‐maackiain as the responsible component. Synthetic maackiain showed stereoselectivity for the suppression of IL‐4 gene expression but not for H1R gene expression, suggesting distinct target proteins for transcriptional signaling. (−)‐Maackiain inhibited of PKCδ translocation to the Golgi and phosphorylation of Tyr311 on PKCδ, which led to the suppression of H1R gene transcription. However, (−)‐maackiain did not show any antioxidant activity or inhibition of PKCδ enzymatic activity per se. Pretreatment with maackiain alleviated nasal symptoms and suppressed TDI‐induced upregulations of H1R and IL‐4 gene expressions in TDI‐sensitized rats. These data suggest that (−)‐maackiain is a novel antiallergic compound that alleviates nasal symptoms in TDI‐sensitized allergy model rats through the inhibition of H1R and IL‐4 gene expression. The molecular mechanism underlying its suppressive effect for H1R gene expression is mediated by the inhibition of PKCδ activation. |
|
言語 |
en |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Allergic disease sensitive gene |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
histamine H1 receptor gene |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
IL-4 gene |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Kujin |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
maackiain |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
PKCδ |
| 書誌情報 |
en : Pharmacology Research & Perspectives
巻 3,
号 5,
p. e00166,
発行日 2015-08-10
|
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
20521707 |
| 出版者 |
|
|
出版者 |
John Wiley & Sons |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
British Pharmacological Society |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
American Society for Pharmacology and Experimental Therapeutics |
|
言語 |
en |
| 権利情報 |
|
|
言語 |
en |
|
権利情報 |
This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
| EID |
|
|
識別子 |
311101 |
|
識別子タイプ |
URI |
| 言語 |
|
|
言語 |
eng |
prp_3_5_e00166.pdf (974 KB)
.png)
