| Item type |
文献 / Documents(1) |
| 公開日 |
2021-08-20 |
| アクセス権 |
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アクセス権 |
open access |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 出版社版DOI |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.1073/pnas.1807297116 |
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言語 |
ja |
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|
関連名称 |
10.1073/pnas.1807297116 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
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|
タイトル |
Conserved fungal effector suppresses PAMP-triggered immunity by targeting plant immune kinases |
|
言語 |
en |
| 著者 |
イリエダ, ヒロキ
イノウエ, ヨシヒロ
モリ, マサシ
山田, 晃嗣
オシカワ, ユウ
サイトウ, ヒロマサ
ウエムラ, アイコ
テラウチ, リョウヘイ
キタクラ, サエコ
コサカ, アユミ
オガワ
タカノ, ヨシタカ
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| 抄録 |
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|
内容記述タイプ |
Abstract |
|
内容記述 |
Plant pathogens have optimized their own effector sets to adapt to their hosts. However, certain effectors, regarded as core effectors, are conserved among various pathogens, and may therefore play an important and common role in pathogen virulence. We report here that the widely distributed fungal effector NIS1 targets host immune components that transmit signaling from pattern recognition receptors (PRRs) in plants. NIS1 from two Colletotrichum spp. suppressed the hypersensitive response and oxidative burst, both of which are induced by pathogen-derived molecules, in Nicotiana benthamiana. Magnaporthe oryzae NIS1 also suppressed the two defense responses, although this pathogen likely acquired the NIS1 gene via horizontal transfer from Basidiomycota. Interestingly, the root endophyte Colletotrichum tofieldiae also possesses a NIS1 homolog that can suppress the oxidative burst in N. benthamiana. We show that NIS1 of multiple pathogens commonly interacts with the PRR-associated kinases BAK1 and BIK1, thereby inhibiting their kinase activities and the BIK1-NADPH oxidase interaction. Furthermore, mutations in the NIS1-targeting proteins, i.e., BAK1 and BIK1, in Arabidopsis thaliana also resulted in reduced immunity to Colletotrichum fungi. Finally, M. oryzae lacking NIS1 displayed significantly reduced virulence on rice and barley, its hosts. Our study therefore reveals that a broad range of filamentous fungi maintain and utilize the core effector NIS1 to establish infection in their host plants and perhaps also beneficial interactions, by targeting conserved and central PRR-associated kinases that are also known to be targeted by bacterial effectors. |
|
言語 |
en |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
BAK1 |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
BIK1 |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
core effector |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
PAMP-triggered immunity |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
phytopathogenic fungi |
| 書誌情報 |
en : Proceedings of the National Academy of Sciences of the United States of America
巻 116,
号 2,
p. 496-505,
発行日 2018-12-24
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| 収録物ID |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
10916490 |
| 収録物ID |
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|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA11726874 |
| 収録物ID |
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|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA12104563 |
| 出版者 |
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|
出版者 |
National Academy of Sciences |
|
言語 |
en |
| 権利情報 |
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|
言語 |
en |
|
権利情報 |
This open access article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND)(https://creativecommons.org/licenses/by-nc-nd/4.0/). |
| EID |
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識別子 |
349797 |
|
識別子タイプ |
URI |
| 言語 |
|
|
言語 |
eng |
pnas_116_2_496.pdf (1.88 MB)
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