| Item type |
文献 / Documents(1) |
| 公開日 |
2021-04-28 |
| アクセス権 |
|
|
アクセス権 |
open access |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
関連識別子 |
https://doi.org/10.1016/j.rmcr.2018.07.008 |
|
|
関連名称 |
10.1016/j.rmcr.2018.07.008 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
A case of pulmonary pleomorphic carcinoma with malignant phenotypes induced by ZEB1-associated epithelial-mesenchymal transition |
| 著者 |
近藤, 真代
荻野, 広和
小川, 博久
Afroj, Tania
豊田, 優子
坂口, 暁
ツボイ, ミキ
坂東, 良美
後東, 久嗣
常山, 幸一
西岡, 安彦
|
| 抄録 |
|
|
内容記述 |
A 60-year-old man was admitted to our hospital with non-small cell lung cancer (NSCLC). Imaging and pathological studies revealed NSCLC, not otherwise specified (NOS), at clinical stage T3N1M0 stage IIIA. We started radiotherapy alone because of obstructive pneumonia and end-stage renal disease, but the tumors progressed rapidly and resulted in death due to air obstruction by pharyngeal metastasis. The cancer was diagnosed as pleomorphic carcinoma in an autopsy. Viable lung tumor cells, which were resistant to radiotherapy, and the pharyngeal metastasis had mesenchymal phenotypes and expressed ZEB1 but not SNAI1. These observations indicated that ZEB1-associated epithelial-mesenchymal transition has malignant features including resistance to radiotherapy and aggressive metastatic potential. ZEB1-associated EMT may be an important mechanism to understand the pathophysiology of pleomorphic carcinoma. |
| キーワード |
|
|
主題 |
Pulmonary pleomorphic carcinoma |
| キーワード |
|
|
主題 |
Epithelial-mesenchymal transition (EMT) |
| キーワード |
|
|
主題 |
ZEB1 |
| 書誌情報 |
en : Respiratory Medicine Case Reports
巻 25,
p. 119-121,
発行日 2018-08-03
|
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
22130071 |
| 出版者 |
|
|
出版者 |
Elsevier |
| 権利情報 |
|
|
権利情報 |
This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| EID |
|
|
識別子 |
347644 |
| 言語 |
|
|
言語 |
eng |
rmcr_25_119.pdf (1.36 MB)
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