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Leukocyte-Mimetic Liposomes Penetrate Into Tumor Spheroids and Suppress Spheroid Growth by Encapsulated Doxorubicin
https://tokushima-u.repo.nii.ac.jp/records/2008678
https://tokushima-u.repo.nii.ac.jp/records/200867832be17e6-ab3b-4761-8d08-171a41feafb2
| 名前 / ファイル | ライセンス | アクション |
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xphs_110_4_1701.pdf (1.07 MB)
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| アイテムタイプ | 文献 / Documents(1) | |||||||||||||||||||||||
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| 公開日 | 2021-03-03 | |||||||||||||||||||||||
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| アクセス権 | open access | |||||||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||||||||
| 出版社版DOI | ||||||||||||||||||||||||
| 関連識別子 | https://doi.org/10.1016/j.xphs.2020.10.049 | |||||||||||||||||||||||
| 関連名称 | 10.1016/j.xphs.2020.10.049 | |||||||||||||||||||||||
| 出版タイプ | ||||||||||||||||||||||||
| 出版タイプ | AM | |||||||||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||||||||||||||||
| タイトル | ||||||||||||||||||||||||
| タイトル | Leukocyte-Mimetic Liposomes Penetrate Into Tumor Spheroids and Suppress Spheroid Growth by Encapsulated Doxorubicin | |||||||||||||||||||||||
| 著者 |
福田, 達也
× 福田, 達也
WEKO
867
× ヨシミ, シンタロウ
× 小暮, 健太朗
WEKO
1139
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| 内容記述 | As leukocytes can penetrate into deep regions of a tumor mass, leukocyte-mimetic liposomes (LM-Lipo) containing leukocyte membrane proteins are also expected to penetrate into tumors by exerting properties of those membrane proteins. The aim of the present study was to examine whether LM-Lipo, which were recently demonstrated to actively pass through inflamed endothelial layers, can penetrate into tumor spheroids, and to investigate the potential of LM-Lipo for use as an anticancer drug carrier. We prepared LM-Lipo via intermembrane protein transfer from human leukemia cells; transfer of leukocyte membrane proteins onto the liposomes was determined by Western blotting. LM-Lipo demonstrated a significantly high association with human lung cancer A549 cells compared with plain liposomes, which contributed to effective anti-proliferative action by encapsulated doxorubicin hydrochloride (DOX). Confocal microscopic images showed that LM-Lipo, but not plain liposomes, could efficiently penetrate into A549 tumor spheroids. Moreover, DOX-encapsulated LM-Lipo significantly suppressed tumor spheroid growth. Thus, leukocyte membrane proteins transferred onto LM-Lipo retained their unique function, which allowed for efficient penetration of the liposomes into tumor spheroids, similar to leukocytes. In conclusion, these results suggest that LM-Lipo could be a useful tumor-penetrating drug delivery system for cancer treatment. | |||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||
| 主題 | Liposome | |||||||||||||||||||||||
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| 主題 | Leukocyte | |||||||||||||||||||||||
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| 主題 | Leukocyte-mimetic drug delivery system | |||||||||||||||||||||||
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| 主題 | Intermembrane protein transfer | |||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||
| 主題 | Cancer | |||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||
| 主題 | Tumor spheroid | |||||||||||||||||||||||
| 書誌情報 |
en : Journal of Pharmaceutical Sciences 巻 110, 号 4, p. 1701-1709, 発行日 2020-10-28 |
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| 収録物識別子タイプ | ISSN | |||||||||||||||||||||||
| 収録物識別子 | 00223549 | |||||||||||||||||||||||
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| 収録物識別子タイプ | NCID | |||||||||||||||||||||||
| 収録物識別子 | AA00704450 | |||||||||||||||||||||||
| 出版者 | ||||||||||||||||||||||||
| 出版者 | American Pharmacists Association | |||||||||||||||||||||||
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| 出版者 | Elsevier | |||||||||||||||||||||||
| 権利情報 | ||||||||||||||||||||||||
| 権利情報 | © 2020. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ | |||||||||||||||||||||||
| EID | ||||||||||||||||||||||||
| 識別子 | 373040 | |||||||||||||||||||||||
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| 言語 | eng | |||||||||||||||||||||||
