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Detailed evaluation of the upper airway in the Dp(16)1Yey mouse model of Down syndrome
https://tokushima-u.repo.nii.ac.jp/records/2008682
https://tokushima-u.repo.nii.ac.jp/records/200868218126670-f36c-4e68-894a-c192ced826f1
| 名前 / ファイル | ライセンス | アクション |
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srep_10_21323.pdf (1.63 MB)
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| Item type | 文献 / Documents(1) | |||||||||||||||||||||||||||||||||
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| 公開日 | 2021-03-04 | |||||||||||||||||||||||||||||||||
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| アクセス権 | open access | |||||||||||||||||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||||||||||||||||||
| 出版社版DOI | ||||||||||||||||||||||||||||||||||
| 関連識別子 | https://doi.org/10.1038/s41598-020-78278-2 | |||||||||||||||||||||||||||||||||
| 関連名称 | 10.1038/s41598-020-78278-2 | |||||||||||||||||||||||||||||||||
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| 出版タイプ | VoR | |||||||||||||||||||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||||||||||||||||||
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| タイトル | Detailed evaluation of the upper airway in the Dp(16)1Yey mouse model of Down syndrome | |||||||||||||||||||||||||||||||||
| 著者 |
タカハシ, タツノリ
× タカハシ, タツノリ
× サカイ, ノリアキ
× 岩﨑, 智憲
WEKO
1420
× Doyle, Timothy C.
× Mobley, William C.
× ニシノ, セイジ
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| 内容記述 | A high prevalence of obstructive sleep apnea (OSA) has been reported in Down syndrome (DS) owing to the coexistence of multiple predisposing factors related to its genetic abnormality, posing a challenge for the management of OSA. We hypothesized that DS mice recapitulate craniofacial abnormalities and upper airway obstruction of human DS and can serve as an experimental platform for OSA research. This study, thus, aimed to quantitatively characterize the upper airway as well as craniofacial abnormalities in Dp(16)1Yey (Dp16) mice. Dp16 mice demonstrated craniofacial hypoplasia, especially in the ventral part of the skull and the mandible, and rostrally positioned hyoid. These changes were accompanied with a shorter length and smaller cross-sectional area of the upper airway, resulting in a significantly reduced upper airway volume in Dp16 mice. Our non-invasive approach, a combination of computational fluid dynamics and high-resolution micro-CT imaging, revealed a higher negative pressure inside the airway of Dp16 mice compared to wild-type littermates, showing the potential risk of upper airway collapse. Our study indicated that Dp16 mice can be a useful model to examine the pathophysiology of increased upper airway collapsibility of DS and to evaluate the efficacy of therapeutic interventions for breathing and sleep anomalies. | |||||||||||||||||||||||||||||||||
| 書誌情報 |
en : Scientific Reports 巻 10, p. 21323, 発行日 2020-12-07 |
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| 収録物識別子タイプ | ISSN | |||||||||||||||||||||||||||||||||
| 収録物識別子 | 20452322 | |||||||||||||||||||||||||||||||||
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| 出版者 | Springer Nature | |||||||||||||||||||||||||||||||||
| 権利情報 | ||||||||||||||||||||||||||||||||||
| 権利情報 | This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. | |||||||||||||||||||||||||||||||||
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| 識別子 | 373815 | |||||||||||||||||||||||||||||||||
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| 言語 | eng | |||||||||||||||||||||||||||||||||
