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Oral vaccination with influenza hemagglutinin combined with human pulmonary surfactant-mimicking synthetic adjuvant SF-10 induces efficient local and systemic immunity compared with nasal and subcutaneous vaccination and provides protective immunity in mice
https://tokushima-u.repo.nii.ac.jp/records/2008747
https://tokushima-u.repo.nii.ac.jp/records/2008747be223199-5295-4c33-bf44-641efd2669bd
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
vaccine_37_4_612.pdf (2.11 MB)
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| Item type | 文献 / Documents(1) | |||||||||||||||||||||||||
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| 公開日 | 2021-06-03 | |||||||||||||||||||||||||
| アクセス権 | ||||||||||||||||||||||||||
| アクセス権 | open access | |||||||||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||||||||||
| 出版社版DOI | ||||||||||||||||||||||||||
| 関連識別子 | https://doi.org/10.1016/j.vaccine.2018.12.002 | |||||||||||||||||||||||||
| 関連名称 | 10.1016/j.vaccine.2018.12.002 | |||||||||||||||||||||||||
| 出版タイプ | ||||||||||||||||||||||||||
| 出版タイプ | VoR | |||||||||||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||||||||||
| タイトル | ||||||||||||||||||||||||||
| タイトル | Oral vaccination with influenza hemagglutinin combined with human pulmonary surfactant-mimicking synthetic adjuvant SF-10 induces efficient local and systemic immunity compared with nasal and subcutaneous vaccination and provides protective immunity in mice | |||||||||||||||||||||||||
| 著者 |
木本, 貴士
× 木本, 貴士× Kim, Hyejin
× サカイ, サトコ
× 高橋, 悦久
WEKO
391
× 木戸, 博
WEKO
173
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| 抄録 | ||||||||||||||||||||||||||
| 内容記述 | We reported previously that a synthetic mucosal adjuvant SF-10, which mimics human pulmonary surfactant, delivers antigen to mucosal dendritic cells in the nasal cavity and promotes induction of humoral and cellular immunity. The aim of the present study was to determine the effects of oral administration of antigen combined with SF-10 (antigen-SF-10) on systemic and local immunity. Oral administration of ovalbumin, a model antigen, combined with SF-10 enhanced ovalbumin uptake into intestinal antigen presenting MHC II+CD11c+ cells and their CD11b+CD103+ and CD11b+CD103- subtype dendritic cells, which are the major antigen presenting subsets of the intestinal tract, more efficiently compared to without SF-10. Oral vaccination with influenza hemagglutinin vaccine (HAv)-SF-10 induced HAv-specific IgA and IgG in the serum, and HAv-specific secretory IgA and IgG in bronchoalveolar lavage fluid, nasal washes, gastric extracts and fecal material; their levels were significantly higher than those induced by subcutaneous HAv or intranasal HAv and HAv-SF-10 vaccinations. Enzyme-linked immunospot assay showed high numbers of HAv-specific IgA and IgG antibody secreting cells in the gastrointestinal and respiratory mucosal lymphoid tissues after oral vaccination with HAv-SF-10, but no or very low induction following oral vaccination with HAv alone. Oral vaccination with HAv-SF-10 provided protective immunity against severe influenza A virus infection, which was significantly higher than that induced by HAv combined with cholera toxin. Oral vaccination with HAv-SF-10 was associated with unique cytokine production patterns in the spleen after HAv stimulation; including marked induction of HAv-responsive Th17 cytokines (e.g., IL-17A and IL-22), high induction of Th1 cytokines (e.g., IL-2 and IFN-γ) and moderate induction of Th2 cytokines (e.g., IL-4 and IL-5). These results indicate that oral vaccination with HAv-SF-10 induces more efficient systemic and local immunity than nasal or subcutaneous vaccination with characteristically high levels of secretory HAv-specific IgA in various mucosal organs and protective immunity. | |||||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||||
| 主題 | Pulmonary surfactant | |||||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||||
| 主題 | Synthetic mucosal adjuvant | |||||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||||
| 主題 | Oral vaccination | |||||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||||
| 主題 | Gastrointestinal immunity | |||||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||||
| 主題 | Influenza vaccine | |||||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||||
| 主題 | Th17 cytokine | |||||||||||||||||||||||||
| 書誌情報 |
en : Vaccine 巻 37, 号 4, p. 612-622, 発行日 2018-12-13 |
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| 収録物識別子タイプ | ISSN | |||||||||||||||||||||||||
| 収録物識別子 | 0264410X | |||||||||||||||||||||||||
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| 収録物識別子タイプ | NCID | |||||||||||||||||||||||||
| 収録物識別子 | AA11541256 | |||||||||||||||||||||||||
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| 収録物識別子タイプ | NCID | |||||||||||||||||||||||||
| 収録物識別子 | AA10491877 | |||||||||||||||||||||||||
| 出版者 | ||||||||||||||||||||||||||
| 出版者 | Elsevier | |||||||||||||||||||||||||
| 権利情報 | ||||||||||||||||||||||||||
| 権利情報 | This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). | |||||||||||||||||||||||||
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| 識別子 | 356468 | |||||||||||||||||||||||||
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| 言語 | eng | |||||||||||||||||||||||||
