| Item type |
文献 / Documents(1) |
| 公開日 |
2021-08-20 |
| アクセス権 |
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|
アクセス権 |
open access |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 出版社版DOI |
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関連識別子 |
https://doi.org/10.1083/jcb.201907079 |
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関連名称 |
10.1083/jcb.201907079 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
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|
タイトル |
Afadin regulates actomyosin organization through αE-catenin at adherens junctions |
| タイトル別表記 |
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その他のタイトル |
Actomyosin organization at adherens junctions |
| 著者 |
榊原, 正太郎
WEKO
991
| ja |
榊原, 正太郎
ISNI
|
| ja-Kana |
サカキバラ, ショウタロウ
|
| en |
Sakakibara, Shotaro
|
Search repository
ミズタニ, キヨヒト
スギウラ, アユム
坂根, 亜由子
佐々木, 卓也
米村, 重信
タカイ, ヨシミ
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| 抄録 |
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内容記述 |
Actomyosin-undercoated adherens junctions are critical for epithelial cell integrity and remodeling. Actomyosin associates with adherens junctions through αE-catenin complexed with β-catenin and E-cadherin in vivo; however, in vitro biochemical studies in solution showed that αE-catenin complexed with β-catenin binds to F-actin less efficiently than αE-catenin that is not complexed with β-catenin. Although a “catch-bond model” partly explains this inconsistency, the mechanism for this inconsistency between the in vivo and in vitro results remains elusive. We herein demonstrate that afadin binds to αE-catenin complexed with β-catenin and enhances its F-actin–binding activity in a novel mechanism, eventually inducing the proper actomyosin organization through αE-catenin complexed with β-catenin and E-cadherin at adherens junctions. |
| 書誌情報 |
en : Journal of Cell Biology
巻 219,
号 5,
p. e201907079,
発行日 2020-03-30
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| 収録物ID |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
00219525 |
| 収録物ID |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
15408140 |
| 収録物ID |
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|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00694812 |
| 収録物ID |
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|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA1203766X |
| 出版者 |
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出版者 |
Rockefeller University Press |
| 権利情報 |
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|
権利情報 |
This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/). |
| EID |
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|
識別子 |
370383 |
| 言語 |
|
|
言語 |
eng |
jcb_219_5_e201907079.pdf (5.61 MB)
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