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Improvement of global longitudinal strain following high-dose chemotherapy and autologous peripheral blood stem cell transplantation in patients with amyloid light-chain cardiac amyloidosis : a case report
https://tokushima-u.repo.nii.ac.jp/records/2008766
https://tokushima-u.repo.nii.ac.jp/records/20087666ace1f6a-05e8-4cbc-a2d0-a3305bc812da
| 名前 / ファイル | ライセンス | アクション |
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ehjcr_3_4_1.pdf (800 KB)
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| Item type | 文献 / Documents(1) | |||||||||||||||||||||||||||||
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| 公開日 | 2021-07-30 | |||||||||||||||||||||||||||||
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| アクセス権 | open access | |||||||||||||||||||||||||||||
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| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||||||||||||||
| 出版社版DOI | ||||||||||||||||||||||||||||||
| 関連識別子 | https://doi.org/10.1093/ehjcr/ytz225 | |||||||||||||||||||||||||||||
| 関連名称 | 10.1093/ehjcr/ytz225 | |||||||||||||||||||||||||||||
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| 出版タイプ | VoR | |||||||||||||||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||||||||||||||
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| タイトル | Improvement of global longitudinal strain following high-dose chemotherapy and autologous peripheral blood stem cell transplantation in patients with amyloid light-chain cardiac amyloidosis : a case report | |||||||||||||||||||||||||||||
| タイトル別表記 | ||||||||||||||||||||||||||||||
| その他のタイトル | GLS following high-dose chemotherapy | |||||||||||||||||||||||||||||
| 著者 |
ヒラタ, ユキナ
× ヒラタ, ユキナ
× 楠瀬, 賢也
WEKO
231
× 三木, 浩和
WEKO
580
× 山田, 博胤
WEKO
197
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| 内容記述 | Background Cardiac amyloidosis (CA) is a secondary form of cardiomyopathy where abnormal accumulation of amyloid protein in the myocardial interstitium causes cardiac hypertrophy and myocardial fibrosis. If primary CA advances to heart failure, most patients do not survive for very long after the diagnosis. Case summary A 40-year-old man was admitted to our hospital for dyspnoea, progressive anaemia, and decreased appetite. He has diagnosed with amyloid light-chain (AL) amyloidosis. Although BD treatment (bortezomib + dexamethasone) and medical treatment were started, there was no sign of improvement. Then, high-dose chemotherapy followed by autologous peripheral blood stem cell transplantation (auto-PBSCT) was initiated. Pretreatment echocardiography revealed typical findings of CA, such as ventricular wall thickening, valvular thickening, diastolic dysfunction, and pericardial effusion. Global longitudinal strain (GLS) was significantly reduced, and bull's-eye mapping showed typical apical sparing. After auto-PBSCT, GLS gradually improved and was almost normal after 2 years. Other echocardiographic parameters, functional status, and laboratory data also showed that there was significant regression of CA. Discussion Although the prognosis in primary CA is extremely poor, we achieved long-term survival in a patient with effective high-dose chemotherapy and auto-PBSCT. Global longitudinal strain may be a useful marker of prognosis, regression, and recovery. |
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| 主題 | Cardiac amyloidosis | |||||||||||||||||||||||||||||
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| 主題 | Echocardiography | |||||||||||||||||||||||||||||
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| 主題 | Speckle tracking | |||||||||||||||||||||||||||||
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| 主題 | Global longitudinal strain | |||||||||||||||||||||||||||||
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| 主題 | Improvement | |||||||||||||||||||||||||||||
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| 主題 | Case report | |||||||||||||||||||||||||||||
| 書誌情報 |
en : European Heart Journal: Case Reports 巻 3, 号 4, p. 1-6, 発行日 2019-12-16 |
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| 収録物識別子タイプ | ISSN | |||||||||||||||||||||||||||||
| 収録物識別子 | 25142119 | |||||||||||||||||||||||||||||
| 出版者 | ||||||||||||||||||||||||||||||
| 出版者 | Oxford University Press | |||||||||||||||||||||||||||||
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| 出版者 | European Society of Cardiology | |||||||||||||||||||||||||||||
| 権利情報 | ||||||||||||||||||||||||||||||
| 権利情報 | This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com | |||||||||||||||||||||||||||||
| EID | ||||||||||||||||||||||||||||||
| 識別子 | 367316 | |||||||||||||||||||||||||||||
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| 言語 | eng | |||||||||||||||||||||||||||||
