| Item type |
文献 / Documents(1) |
| 公開日 |
2021-06-25 |
| アクセス権 |
|
|
アクセス権 |
open access |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1111/dom.14109 |
|
|
言語 |
ja |
|
|
関連名称 |
10.1111/dom.14109 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Lower risk of severe hypoglycaemia with insulin glargine 300 U/mL versus glargine 100 U/mL in participants with type 1 diabetes : A meta‐analysis of 6‐month phase 3 clinical trials |
|
言語 |
en |
| 著者 |
Danne, Thomas
松久, 宗英
Sussebach, Christian
Goyeau, Harmonie
Lauand, Felipe
Niemoeller, Elisabeth
Bolli, Geremia B.
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Severe hypoglycaemia (SH) remains a challenge to people with type 1 diabetes (T1DM), and new‐generation basal insulins may improve patient outcomes. This post hoc meta‐analysis explored the risk of SH with insulin glargine 300 U/mL (Gla‐300) versus glargine 100 U/mL (Gla‐100) in a pooled population with T1DM from three randomized, multicentre, 6‐month similarly designed phase 3 trials: EDITION 4, EDITION JP 1 and EDITION JUNIOR. Endpoints included incidence and time to first occurrence of SH. Among 629 and 626 participants randomized to Gla‐300 and Gla‐100, respectively, glycated haemoglobin reductions were similar. Fewer participants experienced ≥1 SH event with Gla‐300 (6.2%) than with Gla‐100 (9.3%). From baseline to month 6, the risk of a first SH event was lower with Gla‐300: hazard ratio 0.65 [95% confidence interval (CI) 0.44–0.98; stratified log‐rank test P = 0.038]. SH event rates were numerically lower with Gla‐300 versus Gla‐100 from baseline to month 6 [relative risk (RR) 0.80 (95% CI 0.49–1.29); P = 0.356] and baseline to week 8 [RR 0.73 (95% CI 0.37–1.44); P = 0.369]. Thus, Gla‐300 demonstrated similar glycaemic control with lower risk of SH versus Gla‐100, particularly during the titration period. |
|
言語 |
en |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
basal insulin |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
glycaemic control |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
hypoglycaemia |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
insulin analogues |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
meta-analysis |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
type 1 diabetes |
| 書誌情報 |
en : Diabetes, Obesity and Metabolism: A Journal of Pharmacology and Therapeutics
巻 22,
号 10,
p. 1880-1885,
発行日 2020-06-09
|
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
14631326 |
| 収録物ID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA11435496 |
| 出版者 |
|
|
出版者 |
John Wiley & Sons |
|
言語 |
en |
| 権利情報 |
|
|
言語 |
en |
|
権利情報 |
This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
| EID |
|
|
識別子 |
367599 |
|
識別子タイプ |
URI |
| 言語 |
|
|
言語 |
eng |
dom_22_10_1880.pdf (582 KB)
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