| Item type |
文献 / Documents(1) |
| 公開日 |
2024-12-19 |
| アクセス権 |
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アクセス権 |
open access |
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アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_db06 |
|
資源タイプ |
doctoral thesis |
| 出版社版DOI |
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関連識別子 |
https://doi.org/10.2152/jmi.69.266 |
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関連名称 |
10.2152/jmi.69.266 |
| 出版タイプ |
|
|
出版タイプ |
NA |
|
出版タイプResource |
http://purl.org/coar/version/c_be7fb7dd8ff6fe43 |
| タイトル |
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|
タイトル |
The quality and quantity of sleep on dexmedetomidine during high-flow nasal cannula oxygen therapy in critically ill patients |
| タイトル別表記 |
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その他のタイトル |
高流量経鼻カニュラ酸素療法中の重症患者における、デクスメデトミジンの睡眠動態に対する効果 |
| タイトル別表記 |
|
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その他のタイトル |
Dexmedetomidine and sleep during HFNC |
| 著者 |
上野, 義豊
Sato, Koji
百田, 和貴
佐藤, 裕紀
Nakano, Yuki
Akimoto, Yusuke
布村, 俊幸
Tane, Natsuki
板垣, 大雅
大藤, 純
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| 抄録 |
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内容記述 |
Purpose : High-flow nasal cannula oxygen therapy (HFNC) is a new type of non-invasive respiratory support for acute respiratory failure patients. However, patients receiving HFNC often develop sleep disturbances. We therefore examined whether dexmedetomidine could preserve the sleep characteristics in patients who underwent HFNC. Patients and Methods : This was a pilot, randomized controlled study. We assigned critically ill patients treated with HFNC to receive dexmedetomidine (0.2 to 0.7 μg / kg / h, DEX group) or not (non-DEX group) at night (9:00 p.m. to 6:00 a.m.). Polysomnograms were monitored during the study period. The primary outcomes were total sleep time (TST), sleep efficiency and duration of stage 2 non-rapid eye movement (stage N2) sleep. Results : Of the 28 patients who underwent randomization, 24 were included in the final analysis (12 patients per group). Dexmedetomidine increased the TST (369 min vs. 119 min, p = 0.024) and sleep efficiency (68% vs. 22%, P = 0.024). The duration of stage N2 was increased in the DEX group compared with the non-DEX group, but this finding did not reach statistical significance. The incidences of respiratory depression and hemodynamic instability were similar between the two groups. Conclusions : In critically ill patients who underwent HFNC, dexmedetomidine may optimize the sleep quantity without any adverse events. |
| キーワード |
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|
主題 |
dexmedetomidine |
| キーワード |
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主題 |
sleep disturbance |
| キーワード |
|
|
主題 |
high-flow nasal cannula oxygen therapy (HFNC) |
| 書誌情報 |
en : The Journal of Medical Investigation
巻 69,
号 3-4,
p. 266-272,
発行日 2022-08
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| 収録物ID |
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収録物識別子タイプ |
EISSN |
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収録物識別子 |
13496867 |
| 収録物ID |
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|
収録物識別子タイプ |
PISSN |
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収録物識別子 |
13431420 |
| 収録物ID |
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収録物識別子タイプ |
NCID |
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収録物識別子 |
AA11166929 |
| 出版者 |
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出版者 |
Tokushima University Faculty of Medicine |
| 備考 |
|
|
値 |
内容要旨・審査要旨・論文本文の公開
本論文は，著者Yoshitoyo Uenoの学位論文として提出され，学位審査・授与の対象となっている。 |
| EID |
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|
識別子 |
399267 |
| 言語 |
|
|
言語 |
eng |
| 報告番号 |
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|
学位授与番号 |
乙第2134号 |
| 学位記番号 |
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|
値 |
乙医第1767号 |
| 学位授与年月日 |
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学位授与年月日 |
2024-09-26 |
| 学位名 |
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学位名 |
博士（医学） |
| 学位授与機関 |
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学位授与機関名 |
徳島大学 |
o2134_abstract.pdf (119 KB)
