| Item type |
文献 / Documents(1) |
| 公開日 |
2021-06-09 |
| アクセス権 |
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アクセス権 |
open access |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_db06 |
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資源タイプ |
doctoral thesis |
| 出版社版DOI |
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関連識別子 |
https://doi.org/10.4049/jimmunol.2000909 |
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関連名称 |
10.4049/jimmunol.2000909 |
| 出版タイプ |
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出版タイプ |
NA |
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出版タイプResource |
http://purl.org/coar/version/c_be7fb7dd8ff6fe43 |
| タイトル |
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タイトル |
Blockade of PD-1/PD-L1 Pathway Enhances the Antigen-Presenting Capacity of Fibrocytes |
| タイトル別表記 |
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その他のタイトル |
PD-1/PD-L1経路の阻害は線維細胞の抗原提示能を増強する |
| タイトル別表記 |
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その他のタイトル |
BLOCKADE OF PD-1/PD-L1 ENHANCES APC FUNCTION OF FIBROCYTES |
| 著者 |
アフローズ, タニア
三橋, 惇志
荻野, 広和
西條, 敦郎
大塚, 憲司
米田, 浩人
飛梅, 亮
Nguyen, Na Thi
後東, 久嗣
小山, 壱也
スギモト, マサミチ
コンドウ, オサム
軒原, 浩
西岡, 安彦
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| 抄録 |
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内容記述 |
Fibrocytes, a distinct population of collagen-producing, monocyte-derived cells, are involved in wound healing as well as fibrotic diseases. Recently, fibrocytes have been revealed to play a role in the tumor microenvironment, particularly under antiangiogenic therapy. In addition, combination cancer immunotherapy with immune checkpoint inhibitor and antiangiogenic agents have been developed for various cancers in the clinical setting, although the immunological background is not clear. In the current study, we aimed to determine the function of fibrocytes in tumor immunity induced by immune checkpoint inhibitor therapy. Human and murine fibrocytes were generated from PBMCs and lungs, respectively. The expression of costimulatory and inhibitory molecules on fibrocytes was examined by flow cytometry. The stimulation of CD8+ T cells by fibrocytes was examined in MLRs with a 3H-thymidine incorporation assay. Fibrocytes expressed CD80low and CD86high as a costimulatory molecule, and expressed PD-L1high, but not PD-L2, as a coinhibitory molecule.Without any stimulation, fibrocytes strongly enhanced the proliferation of CD8+ T cells in mice and humans. Treatment with anti-CD86 and -CD54 Abs inhibited the growth of CD8+ T cells induced by fibrocytes. Anti–PD-L1 Ab further enhanced the proliferation of CD8+ T cells, even in the OVA-specific MLR with OT-1Rag-/- mice. Importantly, fibrocytes derived from PBMCs of patients with lung adenocarcinoma or murine MC38 tumors augmented the proliferation of CD8+ T cells with PD-L1 blockade. These results suggest that fibrocytes infiltrating tumor sites may play a role in the antitumor immunity mediated by CD8+ T cells when the activity is further enhanced by PD-L1/PD-1 blockade. |
| キーワード |
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主題 |
Fibrocytes |
| キーワード |
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主題 |
PD-1/PD-L1 Blockade |
| キーワード |
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主題 |
CD8+ T-cells |
| キーワード |
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主題 |
Antigen-presentation |
| キーワード |
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主題 |
Cancer immunotherapy |
| 書誌情報 |
en : The Journal of Immunology
巻 206,
号 6,
p. 1204-1214,
発行日 2021-01-27
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| 収録物ID |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
00221767 |
| 収録物ID |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
15506606 |
| 収録物ID |
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収録物識別子タイプ |
NCID |
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収録物識別子 |
AA12067070 |
| 収録物ID |
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収録物識別子タイプ |
NCID |
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収録物識別子 |
AA00699656 |
| 収録物ID |
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収録物識別子タイプ |
NCID |
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収録物識別子 |
AA12530845 |
| 出版者 |
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出版者 |
The American Association of Immunologists, Inc. |
| 備考 |
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値 |
内容要旨・審査要旨・論文本文の公開
本論文は，著者Tania Afrojの学位論文として提出され，学位審査・授与の対象となっている。
Originally published in The Journal of Immunology. Tania Afroj, Atsushi Mitsuhashi, Hirokazu Ogino, Atsuro Saijo, Kenji Otsuka, Hiroto Yoneda, Makoto Tobiume, Na Thi Nguyen, Hisatsugu Goto, Kazuya Koyama, Masamichi Sugimoto, Osamu Kondoh, Hiroshi Nokihara and Yasuhiko Nishioka. 2021. Blockade of PD-1/PD-L1 Pathway Enhances the Antigen-Presenting Capacity of Fibrocytes. J. Immunol. Vol.206(6) pp1204-1214.
学位授与者所属 : 徳島大学大学院医科学教育部（医学専攻） |
| 権利情報 |
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権利情報 |
Copyright © 2021 by The American Association of Immunologists, Inc. |
| EID |
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識別子 |
377448 |
| 言語 |
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言語 |
eng |
| 報告番号 |
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学位授与番号 |
甲第3488号 |
| 学位記番号 |
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値 |
甲医第1492号 |
| 学位授与年月日 |
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学位授与年月日 |
2021-03-17 |
| 学位名 |
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学位名 |
博士（医学） |
| 学位授与機関 |
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学位授与機関名 |
徳島大学 |
k3488_abstract_review.pdf (289 KB)
