| Item type |
文献 / Documents(1) |
| 公開日 |
2021-07-12 |
| アクセス権 |
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|
アクセス権 |
open access |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
関連識別子 |
https://doi.org/10.1111/cts.13045 |
|
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関連名称 |
10.1111/cts.13045 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Effects of 5-HT₃ receptor antagonists on cisplatin-induced kidney injury |
| タイトル別表記 |
|
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その他のタイトル |
EFFECTS OF 5-HT₃ RAS ON CDDP-INDUCED AKI |
| 著者 |
合田, 光寛
カンダ, マサヤ
ヨシオカ, トシヒコ
ヨシダ, アミ
ムライ, ヨウイチ
座間味, 義人
相澤, 風花
新村, 貴博
濱野, 裕章
岡田, 直人
八木, 健太
中馬, 真幸
(井澤)石澤, 有紀
石澤, 啓介
|
| 抄録 |
|
|
内容記述 |
Nausea, vomiting, and renal injury are the common adverse effects associated with cisplatin. Cisplatin is excreted via the multidrug and toxin release (MATE) transporter, and the involvement of the MATE transporter in cisplatin-induced kidney injury has been reported. The MATE transporter is also involved in the excretion of ondansetron, but the effects of 5-HT3 receptor antagonists used clinically for cisplatin-induced renal injury have not been elucidated. Therefore, the aim of this study was to investigate the effects of 5-HT3 receptor antagonists in a mouse model of cisplatin-induced kidney injury and to validate the results using medical big data analysis of more than 1.4 million reports and a survey of 3000 hospital medical records. The concomitant use of a first-generation 5-HT3 receptor antagonist (ondansetron, granisetron, or ramosetron) significantly increased cisplatin accumulation in the kidneys and worsened renal damage. Conversely, the concomitant use of palonosetron had no effect on renal function compared with the use of cisplatin alone. Furthermore, an analysis of data from the US Food and Drug Administration Adverse Event Reporting System and retrospective medical records revealed that the combination treatment of cisplatin and a first-generation 5-HT3 receptor antagonist significantly increased the number of reported renal adverse events compared with the combination treatment of cisplatin and a second-generation 5-HT3 receptor antagonist. These results suggest that compared with the first-generation antagonists, second-generation 5-HT3 receptor antagonists do not worsen cisplatin-induced acute kidney injury. The findings should be validated in a prospective controlled trial before implementation in clinical practice. |
| 書誌情報 |
en : Clinical and Translational Science
巻 14,
号 5,
p. 1906-1916,
発行日 2021-05-13
|
| 収録物ID |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
17528062 |
| 収録物ID |
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|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA12625737 |
| 出版者 |
|
|
出版者 |
Wiley |
| 出版者 |
|
|
出版者 |
American Society for Clinical Pharmacology and Therapeutics |
| 権利情報 |
|
|
権利情報 |
This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
| EID |
|
|
識別子 |
375733 |
| 言語 |
|
|
言語 |
eng |
cts_14_5_1906.pdf (591 KB)
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