| Item type |
文献 / Documents(1) |
| 公開日 |
2021-06-24 |
| アクセス権 |
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|
アクセス権 |
open access |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
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|
関連識別子 |
https://doi.org/10.1002/jbm.b.34361 |
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|
関連名称 |
10.1002/jbm.b.34361 |
| 出版タイプ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| タイトル |
|
|
タイトル |
Effects of acidic calcium phosphate concentration on setting reaction and tissue response to β-tricalcium phosphate granular cement |
| 著者 |
福田, 直志
イシカワ, クニオ
秋田, 和也
鎌田, 久美子
栗尾, 奈愛
モリ, ヨシヒデ
宮本, 洋二
|
| 抄録 |
|
|
内容記述 |
Beta-tricalcium phosphate granular cement (β-TCP GC), consisting of β-TCP granules and an acidic calcium phosphate (Ca-P) solution, shows promise in the reconstruction of bone defects as it sets to form interconnected porous structures, i.e., β-TCP granules are bridged with dicalcium phosphate dihydrate (DCPD) crystals. In this study, the effects of acidic Ca-P solution concentration (0–600 mmol/L) on the setting reaction and tissue response to β-TCP GC were investigated. The β-TCP GC set upon mixing with its liquid phase, based on the formation of DCPD crystals, which bridged β-TCP granules to one another. Diametral tensile strength of the set β-TCP GC was relatively the same, at approximately 0.6 MPa, when the Ca-P concentration was 20–600 mmol/L. Due to the setting ability, reconstruction of the rat’s calvarial bone defect using β-TCP GC with 20, 200, and 600 mmol/L Ca-P solution was much easier compared to that with β-TCP granules without setting ability. Four weeks after the reconstruction, the amount of new bone was the same, approximately 17% in both β-TCP GC and β-TCP granules groups. Cellular response to β-TCP granules and β-TCP GC using the 20 mmol/L acidic Ca-P solution was almost the same. However, β-TCP GC using the 200 and 600 mmol/L acidic Ca-P solution showed a more severe inflammatory reaction. It is concluded, therefore, that β-TCP GC, using the 20 mmol/L acidic Ca-P solution, is recommended as this concentration allows surgical techniques to be performed easily and provides good mechanical strength, and the similar cellular response to β-TCP granules. |
| キーワード |
|
|
主題 |
granular cement |
| キーワード |
|
|
主題 |
β-tricalcium phosphate |
| キーワード |
|
|
主題 |
dicalcium phosphate dihydrate |
| キーワード |
|
|
主題 |
self-setting |
| 書誌情報 |
en : Journal of Biomedical Materials Research Part B : Applied Biomaterials
巻 108,
号 1,
p. 22-29,
発行日 2019-03-18
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| 収録物ID |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
15524981 |
| 収録物ID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA11881538 |
| 収録物ID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA12001425 |
| 出版者 |
|
|
出版者 |
John Wiley & Sons |
| 備考 |
|
|
値 |
This is the peer reviewed version of the following article: Fukuda, N, Ishikawa, K, Akita, K, Kamada, K, Kurio, N, Mori, Y, Miyamoto, Y. 2020. Effects of acidic calcium phosphate concentration on setting reaction and tissue response to β-tricalcium phosphate granular cement. J Biomed Mater Res Part B. 2020: 108B: 22– 29., which has been published in final form at https://doi.org/10.1002/jbm.b.34361. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. |
| EID |
|
|
識別子 |
350182 |
| 言語 |
|
|
言語 |
eng |
jbmrb_108_1_22.pdf (4.39 MB)
