| Item type |
文献 / Documents(1) |
| 公開日 |
2021-07-09 |
| アクセス権 |
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アクセス権 |
open access |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 出版社版DOI |
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|
識別子タイプ |
DOI |
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|
関連識別子 |
https://doi.org/10.1111/asj.12676 |
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言語 |
ja |
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|
関連名称 |
10.1111/asj.12676 |
| 出版タイプ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| タイトル |
|
|
タイトル |
Epigenetic modulation on cat-cow interspecies somatic cell nuclear transfer embryos by treatment with trichostatin A |
|
言語 |
en |
| タイトル別表記 |
|
|
その他のタイトル |
Epigenetic changes in histone H3 modification of Cat-Cow interspecies cloned embryos after treatment with the histone deacetylase inhibitor Trichostatin A |
|
言語 |
en |
| タイトル別表記 |
|
|
その他のタイトル |
Histone H3 modification of iSCNT cat-cow embryos after TSA treatment |
|
言語 |
en |
| タイトル別表記 |
|
|
その他のタイトル |
HISTONE H3 MODIFICATION OF ISCNT EMBRYOS |
|
言語 |
en |
| 著者 |
Wittayarat, Manita
サトウ, ヨウコ
Do, Lanh Thi Kim
Chatdarong, Kaywalee
Tharasanit, Theerawat
Techakumphu, Mongkol
タニグチ, マサヤス
音井, 威重
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| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
This study aimed to determine the acetylation patterns on histone H3K9/18/23 and the dimethylation pattern on histone H3K9 during early embryogenesis among 50 nM Trichostatin A (TSA)-treated iSCNT cat-cow embryos, untreated iSCNT cat-cow embryos (control) and bovine in vitro fertilisation (IVF) embryos, because TSA-treated iSCNT embryos are able to develop into blastocysts. The results show that the acetylation levels of H3K9/18/23 in the TSA-treated iSCNT and bovine IVF embryos were higher than those in the control embryos at almost all of the examined stages (2 h post-fusion / post-insemination (PF/PI), pronuclear (PN), two-cell, four-cell and eight-cell stages). At 6 h PF/PI the acetylation levels on H3K9/23 in the TSA-treated iSCNT and bovine IVF embryos were lower than those in the control, and there was no difference in the acetylation levels of H3K18 among the three groups. The acetylation levels of H3K9/23 increased either in the TSA-treated iSCNT or and bovine IVF embryos increased when those embryos developed to the PN and two-cell stages. The dimethylation level of H3K9 in the TSA-treated iSCNT embryos resembled that of the bovine IVF embryos at all examined stages (2h PF/PI, 6 h PF/PI and PN stages), and these levels were greater than those of the control. This result suggests that treatment of iSCNT embryos with TSA modifies the patterns of histone acetylation and dimethylation at certain lysine residues in a manner that is comparable with that seen in IVF embryos during early embryogenesis. |
|
言語 |
en |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
acetylation |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
iSCNT |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
mammal |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
methylation |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
reprogramming |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
cat |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
cow |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
histone |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
interspecies nuclear transfer |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Trichostatin A |
| 書誌情報 |
en : Animal Science Journal
巻 88,
号 4,
p. 593-601,
発行日 2016-08-09
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| 収録物ID |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
17400929 |
| 収録物ID |
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|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA11677214 |
| 出版者 |
|
|
出版者 |
Japanese Society of Animal Science |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
Wiley |
|
言語 |
en |
| 備考 |
|
|
言語 |
ja |
|
値 |
This is the peer reviewed version of the following article: Wittayarat, M., Sato, Y., Do, L. T. K., Chatdarong, K., Tharasanit, T., Techakumphu, M., Taniguchi, M., and Otoi, T. (2017) Epigenetic modulation on cat-cow interspecies somatic cell nuclear transfer embryos by treatment with trichostatin A. Anim Sci J, 88: 593– 601., which has been published in final form at https://doi.org/10.1111/asj.12676. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. |
| EID |
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|
識別子 |
318315 |
|
識別子タイプ |
URI |
| 言語 |
|
|
言語 |
eng |
asj_88_4_593.pdf (962 KB)
