| Item type |
文献 / Documents(1) |
| 公開日 |
2021-08-06 |
| アクセス権 |
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アクセス権 |
open access |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 出版社版DOI |
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関連識別子 |
https://doi.org/10.14814/phy2.14388 |
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関連名称 |
10.14814/phy2.14388 |
| 出版タイプ |
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出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
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|
タイトル |
Acute bout of exercise downregulates thioredoxin-interacting protein expression in rat contracting skeletal muscles |
| 著者 |
羅, 成圭
カワモト, エミ
コシナカ, ケイイチ
イワベ, マイコ
トミガ, ユウキ
イイザワ, ヒロキ
ホンダ, ヒロキ
ヒガキ, ヤスキ
カワナカ, ケンタロウ
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| 抄録 |
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内容記述 |
We previously reported that in rat skeletal muscle, disuse (i.e., decreased muscle contractile activity) rapidly increases thioredoxin-interacting protein (TXNIP), which is implicated in the reduced glucose uptake. Accordingly, we sought herein to (a) determine the effect of exercise (i.e., increased muscle contractile activity) on muscle TXNIP protein expression, and (b) elucidate the mechanisms underlying the changes of TXNIP protein expression in response to exercise. Rat epitrochlearis and soleus muscles were dissected out after an acute bout of 3-hr swimming (without weight loading) or 3-hr treadmill running (15% grade at 9m/min). In a separate protocol, the isolated epitrochlearis and soleus muscles were incubated for 3 hr with AMP-dependent protein kinase activator AICAR. Immediately after the cessation of the 3-hr swimming, the TXNIP protein was decreased in epitrochlearis but not in soleus muscle. Conversely, 3-hr treadmill running decreased the TXNIP protein in soleus but not in epitrochlearis muscle. TXNIP protein was decreased concomitantly with reduced postexercise muscle glycogen, showing that a decrease in TXNIP protein expression occurs in muscles that are recruited during exercise. In addition, 3-hr incubation with AICAR decreased TXNIP protein in both isolated epitrochlearis and soleus muscles. Our results suggest that (a) an acute bout of exercise downregulates TXNIP protein expression in rat contracting skeletal muscles, and (b) the reduction in TXNIP protein expression in contracting muscles is probably mediated by AMPK activation, at least in part. |
| キーワード |
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主題 |
AMP-activated protein kinase |
| キーワード |
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|
主題 |
epitrochlearis |
| キーワード |
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|
主題 |
soleus |
| キーワード |
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|
主題 |
swimming |
| キーワード |
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|
主題 |
treadmill running |
| 書誌情報 |
en : Physiological Reports
巻 8,
号 11,
p. e14388,
発行日 2020-05-31
|
| 収録物ID |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
2051817X |
| 出版者 |
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出版者 |
Wiley |
| 出版者 |
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出版者 |
The Physiological Society |
| 出版者 |
|
|
出版者 |
The American Physiological Society |
| 権利情報 |
|
|
権利情報 |
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
| EID |
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|
識別子 |
366258 |
| 言語 |
|
|
言語 |
eng |
phy_8_11_e14388.pdf (720 KB)
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