| アイテムタイプ |
文献 / Documents(1) |
| 公開日 |
2021-08-24 |
| アクセス権 |
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アクセス権 |
open access |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 出版社版DOI |
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関連識別子 |
https://doi.org/10.1002/anie.202009966 |
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関連名称 |
10.1002/anie.202009966 |
| 出版タイプ |
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出版タイプ |
AM |
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出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| タイトル |
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タイトル |
Concise Total Synthesis of Tronocarpine |
| 著者 |
中山, 淳
ナカムラ, テンタ
ザイマ, トシヒロ
フジモト, サホ
カランジット, サンギータ
難波, 康祐
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| 抄録 |
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内容記述 |
A concise total synthesis of tronocarpine, a chippiine-type indole alkaloid, was accomplished. The key feature of this total synthesis is a one-pot construction of the pentacyclic skeleton containing an azabicyclo[3.3.1]nonane core by tandem cyclization from an indole derivative having all carbon side chains and functional groups. This tandem cyclization consists of α,β-unsaturated aldehyde formation, intramolecular aldol reaction, six-membered lactamization, azide reduction, and seven-membered lactamization. The stereochemical outcome in this tandem cyclization is controlled by the stereocenter at the C14 position. This strategy can be utilized to synthesize other chippiine-type alkaloids with azabicyclo[3.3.1]nonane skeletons. |
| キーワード |
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主題 |
total synthesis |
| キーワード |
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主題 |
natural product |
| キーワード |
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主題 |
tandem cyclization |
| キーワード |
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主題 |
equilibrium |
| キーワード |
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主題 |
alkaloid |
| 書誌情報 |
en : Angewandte Chemie International Edition
巻 60,
号 2,
p. 635-639,
発行日 2020-09-24
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| 収録物ID |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
14337851 |
| 収録物ID |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
15213773 |
| 収録物ID |
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収録物識別子タイプ |
NCID |
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収録物識別子 |
AA0052535X |
| 出版者 |
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出版者 |
Wiley-VCH |
| 出版者 |
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出版者 |
German Chemical Society |
| 権利情報 |
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権利情報 |
This is the peer reviewed version of the following article: A. Nakayama, T. Nakamura, T. Zaima, S. Fujimoto, S. Karanjit, K. Namba, Angew. Chem. Int. Ed. 2021, 60, 635., which has been published in final form at https://doi.org/10.1002/anie.202009966. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited. |
| EID |
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識別子 |
380069 |
| 言語 |
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言語 |
eng |
anie_60_2_635.pdf (653 KB)
