| Item type |
文献 / Documents(1) |
| 公開日 |
2021-08-24 |
| アクセス権 |
|
|
アクセス権 |
open access |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1016/j.bbadis.2021.166236 |
|
|
言語 |
ja |
|
|
関連名称 |
10.1016/j.bbadis.2021.166236 |
| 出版タイプ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| タイトル |
|
|
タイトル |
Extracellular vesicles of P. gingivalis-infected macrophages induce lung injury |
|
言語 |
en |
| 著者 |
ヨシダ, カヨ
吉田, 賀弥
藤原, 奈津美
瀬山, 真莉子
オノ, キショウ
カワイ, ホタカ
Guo, Jiajie
Wang, Ziyi
Weng, Yao
Yu, Yaqiong
ウチダ フクハラ, ヨウコ
イケガメ, ミカ
ササキ, アキラ
ナガツカ, ヒトシ
カミオカ, ヒロシ
岡村, 裕彦
尾崎, 和美
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Periodontal diseases are common inflammatory diseases that are induced by infection with periodontal bacteria such as Porphyromonas gingivalis (Pg). The association between periodontal diseases and many types of systemic diseases has been demonstrated; the term “periodontal medicine” is used to describe how periodontal infection/inflammation may impact extraoral health. However, the molecular mechanisms by which the factors produced in the oral cavity reach multiple distant organs and impact general health have not been elucidated. Extracellular vesicles (EVs) are nano-sized spherical structures secreted by various types of cells into the tissue microenvironment, and influence pathophysiological conditions by delivering their cargo. However, a detailed understanding of the effect of EVs on periodontal medicine is lacking. In this study, we investigated whether EVs derived from Pg-infected macrophages reach distant organs in mice and influence the pathophysiological status. EVs were isolated from human macrophages, THP-1 cells, infected with Pg. We observed that EVs from Pg-infected THP-1 cells (Pg-inf EVs) contained abundant core histone proteins such as histone H3 and translocated to the lungs, liver, and kidneys of mice. Pg-inf EVs also induced pulmonary injury, including edema, vascular congestion, inflammation, and collagen deposition causing alveoli destruction. The Pg-inf EVs or the recombinant histone H3 activated the NF-κB pathway, leading to increase in the levels of pro-inflammatory cytokines in human lung epithelial A549 cells. Our results suggest a possible mechanism by which EVs produced in periodontal diseases contribute to the progression of periodontal medicine. |
|
言語 |
en |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Periodontal diseases |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Lung diseases |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Infection |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Inflammation |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Epithelial cells |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Animal experimentation |
| 書誌情報 |
en : Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
巻 1867,
号 11,
p. 166236,
発行日 2021-08-11
|
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
09254439 |
| 収録物ID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA10779707 |
| 収録物ID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA11522998 |
| 出版者 |
|
|
出版者 |
Elsevier |
|
言語 |
en |
| 権利情報 |
|
|
言語 |
en |
|
権利情報 |
© 2021. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| EID |
|
|
識別子 |
380408 |
|
識別子タイプ |
URI |
| 言語 |
|
|
言語 |
eng |
bbadis_1867_11_166236.pdf (1.61 MB)
