| Item type |
文献 / Documents(1) |
| 公開日 |
2021-09-08 |
| アクセス権 |
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|
アクセス権 |
open access |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1016/j.stemcr.2020.06.013 |
|
|
言語 |
ja |
|
|
関連名称 |
10.1016/j.stemcr.2020.06.013 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
H3K9 Demethylases JMJD1A and JMJD1B Control Prospermatogonia to Spermatogonia Transition in Mouse Germline |
|
言語 |
en |
| 著者 |
黒木, 俊介
マエダ, リョウ
矢野, 雅司
キタノ, サツキ
ミヤチ, ヒトシ
フクダ, ミキコ
シンカイ, ヨウイチ
立花, 誠
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Histone H3 lysine 9 (H3K9) methylation is dynamically regulated by methyltransferases and demethylases. In spermatogenesis, prospermatogonia differentiate into differentiating or undifferentiated spermatogonia after birth. However, the epigenetic regulation of prospermatogonia to spermatogonia transition is largely unknown. We found that perinatal prospermatogonia have extremely low levels of di-methylated H3K9 (H3K9me2) and that H3K9 demethylases, JMJD1A and JMJD1B, catalyze H3K9me2 demethylation in perinatal prospermatogonia. Depletion of JMJD1A and JMJD1B in the embryonic germline resulted in complete loss of male germ cells after puberty, indicating that H3K9me2 demethylation is essential for male germline maintenance. JMJD1A/JMJD1B-depleted germ cells were unable to differentiate into functional spermatogonia. JMJD1 isozymes contributed to activation of several spermatogonial stem cell maintenance genes through H3K9 demethylation during the prospermatogonia to spermatogonia transition, which we propose is key for spermatogonia development. In summary, JMJD1A/JMJD1B-mediated H3K9me2 demethylation promotes prospermatogonia to differentiate into functional spermatogonia by establishing proper gene expression profiles. |
|
言語 |
en |
| 書誌情報 |
en : Stem Cell Reports
巻 15,
号 2,
p. 424-438,
発行日 2020-07-16
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| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
22136711 |
| 出版者 |
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|
出版者 |
International Society for Stem Cell Research |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
Cell Press |
|
言語 |
en |
| 権利情報 |
|
|
言語 |
en |
|
権利情報 |
This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| EID |
|
|
識別子 |
370445 |
|
識別子タイプ |
URI |
| 言語 |
|
|
言語 |
eng |
stemcr_15_2_424.pdf (5.29 MB)
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