| Item type |
文献 / Documents(1) |
| 公開日 |
2021-10-20 |
| アクセス権 |
|
|
アクセス権 |
open access |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.3390/ijms22063268 |
|
|
言語 |
ja |
|
|
関連名称 |
10.3390/ijms22063268 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Vaporized Hydrogen Peroxide and Ozone Gas Synergistically Reduce Prion Infectivity on Stainless Steel Wire |
|
言語 |
en |
| 著者 |
原, 英之
千田, 淳司
Pasiana, Agriani Dini
内山, 圭司
キクチ, ユタカ
ナイトウ, トモコ
タカハシ, ユウイチ
ヤマムラ, ジュンジ
クロマツ, ヒサシ
坂口, 末廣
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Prions are infectious agents causing prion diseases, which include Creutzfeldt–Jakob disease (CJD) in humans. Several cases have been reported to be transmitted through medical instruments that were used for preclinical CJD patients, raising public health concerns on iatrogenic transmissions of the disease. Since preclinical CJD patients are currently difficult to identify, medical instruments need to be adequately sterilized so as not to transmit the disease. In this study, we investigated the sterilizing activity of two oxidizing agents, ozone gas and vaporized hydrogen peroxide, against prions fixed on stainless steel wires using a mouse bioassay. Mice intracerebrally implanted with prion-contaminated stainless steel wires treated with ozone gas or vaporized hydrogen peroxide developed prion disease later than those implanted with control prion-contaminated stainless steel wires, indicating that ozone gas and vaporized hydrogen peroxide could reduce prion infectivity on wires. Incubation times were further elongated in mice implanted with prion-contaminated stainless steel wires treated with ozone gas-mixed vaporized hydrogen peroxide, indicating that ozone gas mixed with vaporized hydrogen peroxide reduces prions on these wires more potently than ozone gas or vaporized hydrogen peroxide. These results suggest that ozone gas mixed with vaporized hydrogen peroxide might be more useful for prion sterilization than ozone gas or vaporized hydrogen peroxide alone. |
|
言語 |
en |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
prion |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
prion disease |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Creutzfeldt–Jakob disease |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
ozone gas |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
hydrogen peroxide gas |
| 書誌情報 |
en : International Journal of Molecular Sciences
巻 22,
号 6,
p. 3268,
発行日 2021-03-23
|
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
14220067 |
| 出版者 |
|
|
出版者 |
MDPI |
|
言語 |
en |
| 権利情報 |
|
|
言語 |
en |
|
権利情報 |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
| EID |
|
|
識別子 |
375320 |
|
識別子タイプ |
URI |
| 言語 |
|
|
言語 |
eng |
ijms_22_6_3268.pdf (1.9 MB)
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