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Diagnosis of visceral pleural invasion using confocal laser endomicroscopy during lung cancer surgery
https://tokushima-u.repo.nii.ac.jp/records/2009299
https://tokushima-u.repo.nii.ac.jp/records/2009299712b5bce-d632-47fe-9ec9-0c85e0ffee39
| 名前 / ファイル | ライセンス | アクション |
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k3555_abstract_review.pdf (327 KB)
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k3555_fulltext.pdf (1.85 MB)
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| Item type | 文献 / Documents(1) | |||||||||||
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| 公開日 | 2021-10-13 | |||||||||||
| アクセス権 | ||||||||||||
| アクセス権 | open access | |||||||||||
| 資源タイプ | ||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||||||||
| 資源タイプ | doctoral thesis | |||||||||||
| 出版社版DOI | ||||||||||||
| 識別子タイプ | DOI | |||||||||||
| 関連識別子 | https://doi.org/10.21037/jtd-21-137 | |||||||||||
| 言語 | ja | |||||||||||
| 関連名称 | 10.21037/jtd-21-137 | |||||||||||
| 出版タイプ | ||||||||||||
| 出版タイプ | NA | |||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_be7fb7dd8ff6fe43 | |||||||||||
| タイトル | ||||||||||||
| タイトル | Diagnosis of visceral pleural invasion using confocal laser endomicroscopy during lung cancer surgery | |||||||||||
| 言語 | en | |||||||||||
| タイトル別表記 | ||||||||||||
| その他のタイトル | 共焦点レーザー内視鏡を用いた肺癌手術における臓側胸膜浸潤診断 | |||||||||||
| 言語 | ja | |||||||||||
| タイトル別表記 | ||||||||||||
| その他のタイトル | CLE for visceral pleural invasion | |||||||||||
| 言語 | en | |||||||||||
| 著者 |
澤田, 徹
× 澤田, 徹
× 滝沢, 宏光× 青山, 万理子× 河北, 直也× 宮本, 直輝× 坂本, 晋一× 髙嶋, 美佳× 松本, 大資× 鳥羽, 博明× 川上, 行奎× 吉田, 光輝× 近藤, 和也× 丹黒, 章 |
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| 抄録 | ||||||||||||
| 内容記述タイプ | Abstract | |||||||||||
| 内容記述 | Background: Visceral pleural invasion (VPI) in lung cancer is a significant prognostic factor; however, it is difficult to diagnose preoperatively or intraoperatively. In this study, we examined the possibility of intraoperative diagnosis of VPI using confocal laser endomicroscopy (CLE). Methods: Among patients with primary lung cancer who underwent surgery between April 2018 and August 2019, those in whom the tumor was in contact with the pleura on chest computed tomography and whose pleural changes were intraoperatively confirmed were enrolled in this study. In the 35 patients who underwent lung resection (6 cases with visceral pleural infiltration), the area where pleural change was noted was observed and a short video was recorded using CLE. Based on the video images, three evaluators determined the defect ratio (0%, 25%, 50%, 75%, and 100%) of the autofluorescence-positive structure. The area under the receiver operating characteristic curve was used to evaluate the diagnostic performance for VPI. In 15 cases (3 cases with VPI), a validation study was performed for intraoperative VPI according to the cutoff value of the defect ratio of the autofluorescence-positive structure. Results: The areas under the receiver operating characteristic curve for the defect ratio of the autofluorescence-positive structure were 0.86–0.91 for the three readers. Using defect ratio of autofluorescence-positive structure cutoff of ≥50% as predictor of VPI, the sensitivity, specificity, positive predictive value, negative predictive value, and accuracy were 83.3–100.0%, 57.7–73.1%, 35.3–41.7%, 95.0–100.0%, and 75.0–78.1%, respectively, for the three readers. In the validation study, the sensitivity was 100%, the specificity was 83.3%, and the diagnostic accuracy rate was 86.7%. Conclusions: The diagnosis of VPI through CLE is simple, non-invasive, and has high diagnostic accuracy rates. This method may be applicable for determining surgical procedures. |
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| 言語 | en | |||||||||||
| キーワード | ||||||||||||
| 言語 | ja | |||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | 肺癌 | |||||||||||
| キーワード | ||||||||||||
| 言語 | ja | |||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | 胸膜浸潤 | |||||||||||
| キーワード | ||||||||||||
| 言語 | ja | |||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | 共焦点 | |||||||||||
| キーワード | ||||||||||||
| 言語 | ja | |||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | 自家蛍光 | |||||||||||
| キーワード | ||||||||||||
| 言語 | ja | |||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | 診断 | |||||||||||
| キーワード | ||||||||||||
| 言語 | en | |||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | Lung cancer | |||||||||||
| キーワード | ||||||||||||
| 言語 | en | |||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | visceral pleural invasion (VPI) | |||||||||||
| キーワード | ||||||||||||
| 言語 | en | |||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | confocal laser endomicroscopy (CLE) | |||||||||||
| 書誌情報 |
en : Journal of Thoracic Disease 巻 13, 号 8, p. 4742-4752, 発行日 2021-08 |
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| 収録物ID | ||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||
| 収録物識別子 | 20721439 | |||||||||||
| 収録物ID | ||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||
| 収録物識別子 | 20776624 | |||||||||||
| 出版者 | ||||||||||||
| 出版者 | AME Publishing Company | |||||||||||
| 言語 | en | |||||||||||
| 備考 | ||||||||||||
| 言語 | ja | |||||||||||
| 値 | 内容要旨・審査要旨・論文本文の公開 本論文は,著者Toru Sawadaの学位論文として提出され, 学位審査・授与の対象となっている。 学位授与者所属 : 徳島大学大学院医科学教育部（医学専攻） |
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| 権利情報 | ||||||||||||
| 言語 | en | |||||||||||
| 権利情報 | This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0/ |
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| EID | ||||||||||||
| 識別子 | 383777 | |||||||||||
| 識別子タイプ | URI | |||||||||||
| 言語 | ||||||||||||
| 言語 | eng | |||||||||||
| 報告番号 | ||||||||||||
| 学位授与番号 | 甲第3555号 | |||||||||||
| 学位記番号 | ||||||||||||
| 言語 | ja | |||||||||||
| 値 | 甲医第1508号 | |||||||||||
| 学位授与年月日 | ||||||||||||
| 学位授与年月日 | 2021-09-30 | |||||||||||
| 学位名 | ||||||||||||
| 言語 | ja | |||||||||||
| 学位名 | 博士（医学） | |||||||||||
| 学位授与機関 | ||||||||||||
| 言語 | ja | |||||||||||
| 学位授与機関名 | 徳島大学 | |||||||||||
