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The Role of Proteasomes in the Thymus
https://tokushima-u.repo.nii.ac.jp/records/2009305
https://tokushima-u.repo.nii.ac.jp/records/20093056a4bc739-c000-417c-88a9-39528dce38ba
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
fimmu_12_646209.pdf (389 KB)
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| Item type | 文献 / Documents(1) | |||||||||||||||||||
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| 公開日 | 2021-10-18 | |||||||||||||||||||
| アクセス権 | ||||||||||||||||||||
| アクセス権 | open access | |||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||||
| 出版社版DOI | ||||||||||||||||||||
| 関連識別子 | https://doi.org/10.3389/fimmu.2021.646209 | |||||||||||||||||||
| 関連名称 | 10.3389/fimmu.2021.646209 | |||||||||||||||||||
| 出版タイプ | ||||||||||||||||||||
| 出版タイプ | VoR | |||||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||||
| タイトル | ||||||||||||||||||||
| タイトル | The Role of Proteasomes in the Thymus | |||||||||||||||||||
| タイトル別表記 | ||||||||||||||||||||
| その他のタイトル | Proteasomes in the Thymus | |||||||||||||||||||
| 著者 |
Frantzeskakis, Melina
× Frantzeskakis, Melina
× 高浜, 洋介
WEKO
1519
× 大東, いずみ
WEKO
424
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| 抄録 | ||||||||||||||||||||
| 内容記述 | The thymus provides a microenvironment that supports the generation and selection of T cells. Cortical thymic epithelial cells (cTECs) and medullary thymic epithelial cells (mTECs) are essential components of the thymic microenvironment and present MHC-associated self-antigens to developing thymocytes for the generation of immunocompetent and self-tolerant T cells. Proteasomes are multicomponent protease complexes that degrade ubiquitinated proteins and produce peptides that are destined to be associated with MHC class I molecules. cTECs specifically express thymoproteasomes that are essential for optimal positive selection of CD8+ T cells, whereas mTECs, which contribute to the establishment of self-tolerance in T cells, express immunoproteasomes. Immunoproteasomes are also detectable in dendritic cells and developing thymocytes, additionally contributing to T cell development in the thymus. In this review, we summarize the functions of proteasomes expressed in the thymus, focusing on recent findings pertaining to the functions of the thymoproteasomes and the immunoproteasomes. | |||||||||||||||||||
| キーワード | ||||||||||||||||||||
| 主題 | thymus | |||||||||||||||||||
| キーワード | ||||||||||||||||||||
| 主題 | TEC | |||||||||||||||||||
| キーワード | ||||||||||||||||||||
| 主題 | thymoproteasome | |||||||||||||||||||
| キーワード | ||||||||||||||||||||
| 主題 | immunoproteasome | |||||||||||||||||||
| キーワード | ||||||||||||||||||||
| 主題 | thymic selection | |||||||||||||||||||
| 書誌情報 |
en : Frontiers in Immunology 巻 12, p. 646209, 発行日 2021-03-19 |
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| 収録物ID | ||||||||||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||||||||||
| 収録物識別子 | 16643224 | |||||||||||||||||||
| 出版者 | ||||||||||||||||||||
| 出版者 | Frontiers Media S.A. | |||||||||||||||||||
| 権利情報 | ||||||||||||||||||||
| 権利情報 | This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. | |||||||||||||||||||
| EID | ||||||||||||||||||||
| 識別子 | 382605 | |||||||||||||||||||
| 言語 | ||||||||||||||||||||
| 言語 | eng | |||||||||||||||||||
