| Item type |
文献 / Documents(1) |
| 公開日 |
2021-10-22 |
| アクセス権 |
|
|
アクセス権 |
open access |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
関連識別子 |
https://doi.org/10.3390/genes12101514 |
|
|
関連名称 |
10.3390/genes12101514 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Isorhamnetin Promotes 53BP1 Recruitment through the Enhancement of ATM Phosphorylation and Protects Mice from Radiation Gastrointestinal Syndrome |
| 著者 |
西山, 祐一
森田, 明典
タツタ, ショウゴ
カナマル, ミサキ
サカウエ, マサヒロ
ウエダ, ケンタ
ショウノ, マナミ
フジタ, リエ
Wang, Bing
ホソイ, ヨシオ
アオキ, シン
スガイ, タケシ
|
| 抄録 |
|
|
内容記述 |
Flavonoids are a subclass of polyphenols which are attractive, due to possessing various physiological activities, including a radioprotective effect. Tumor suppressor p53 is a primary regulator in the radiation response and is involved in the pathogenesis of radiation injuries. In this study, we revealed that isorhamnetin inhibited radiation cell death, and investigated its action mechanism focusing on DNA damage response. Although isorhamnetin moderated p53 activity, it promoted phosphorylation of ataxia telangiectasia mutated (ATM) and enhanced 53BP1 recruitment in irradiated cells. The radioprotective effect of isorhamnetin was not observed in the presence of ATM inhibitor, indicating that its protective effect was dependent on ATM. Furthermore, isorhamnetin-treated mice survived gastrointestinal death caused by a lethal dose of abdominal irradiation. These findings suggested that isorhamnetin enhances the ATM-dependent DNA repair process, which is presumably associated with the suppressive effect against GI syndrome. |
| キーワード |
|
|
主題 |
isorhamnetin |
| キーワード |
|
|
主題 |
radiation hematopoietic syndrome |
| キーワード |
|
|
主題 |
radiation gastrointestinal syndrome |
| キーワード |
|
|
主題 |
DNA damage response |
| キーワード |
|
|
主題 |
p53 |
| キーワード |
|
|
主題 |
p53 target genes |
| キーワード |
|
|
主題 |
53BP1 |
| キーワード |
|
|
主題 |
ATM |
| キーワード |
|
|
主題 |
pS1981-ATM |
| キーワード |
|
|
主題 |
γH2AX |
| 書誌情報 |
en : Genes
巻 12,
号 10,
p. 1514,
発行日 2021-09-26
|
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
20734425 |
| 出版者 |
|
|
出版者 |
MDPI |
| 権利情報 |
|
|
権利情報 |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
| EID |
|
|
識別子 |
382828 |
| 言語 |
|
|
言語 |
eng |
genes_12_10_1514.pdf (1.83 MB)
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