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Bone morphogenetic protein signaling in distal patterning and intercalation during leg regeneration of the cricket, Gryllus bimaculatus
https://tokushima-u.repo.nii.ac.jp/records/2009328
https://tokushima-u.repo.nii.ac.jp/records/20093282aad760c-c209-41ce-b18b-c798ee77c898
| 名前 / ファイル | ライセンス | アクション |
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dgd_60_6_377.pdf (372 KB)
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| Item type | 文献 / Documents(1) | |||||||||||||||||||||||||||||
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| 公開日 | 2021-11-05 | |||||||||||||||||||||||||||||
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| アクセス権 | open access | |||||||||||||||||||||||||||||
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| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||||||||||||||
| 出版社版DOI | ||||||||||||||||||||||||||||||
| 関連識別子 | https://doi.org/10.1111/dgd.12560 | |||||||||||||||||||||||||||||
| 関連名称 | 10.1111/dgd.12560 | |||||||||||||||||||||||||||||
| 出版タイプ | ||||||||||||||||||||||||||||||
| 出版タイプ | AM | |||||||||||||||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||||||||||||||||||||||
| タイトル | ||||||||||||||||||||||||||||||
| タイトル | Bone morphogenetic protein signaling in distal patterning and intercalation during leg regeneration of the cricket, Gryllus bimaculatus | |||||||||||||||||||||||||||||
| タイトル別表記 | ||||||||||||||||||||||||||||||
| その他のタイトル | BMP signaling in distal patterning and intercalation during leg regeneration of the cricket, Gryllus bimaculatus | |||||||||||||||||||||||||||||
| タイトル別表記 | ||||||||||||||||||||||||||||||
| その他のタイトル | Role of BMP signaling in leg regeneration | |||||||||||||||||||||||||||||
| 著者 |
石丸, 善康
× 石丸, 善康
WEKO
787
× バンドウ, テツヤ
× 大内, 淑代× 野地, 澄晴
WEKO
120
× 三戸, 太郎
WEKO
123
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| 抄録 | ||||||||||||||||||||||||||||||
| 内容記述 | The cricket, Gryllus bimaculatus, is a classic model of leg regeneration following amputation. We previously demonstrated that Gryllus decapentaplegic (Gb’dpp) is expressed during leg regeneration, although it remains unclear whether it is essential for this process. In this study, double-stranded RNA targeting the Smad mathers-against-dpp homolog, Gb’mad, was employed to examine the role of Bone morphogenetic protein (BMP) signaling in the leg regeneration process of Gryllus bimaculatus. RNA interference (RNAi)-mediated knockdown of Gb’mad led to a loss of tarsus regeneration at the most distal region of regenerating leg segments. Moreover, we confirmed that the phenotype obtained by knockdown of Dpp type I receptor, Thick veins (Gb’tkv), closely resembled that observed for Gb’mad RNAi crickets, thereby suggesting that the BMP signaling pathway is indispensable for the initial stages of tarsus formation. Interestingly, knockdown of Gb’mad and Gb’tkv resulted in significant elongation of regenerating tibia along the proximodistal axis compared with normal legs. Moreover, our findings indicate that during the regeneration of tibia, the BMP signaling pathway interacts with Dachsous/Fat (Gb’Ds/Gb’Ft) signaling and dachshund (Gb’dac) to re-establish positional information and regulate determination of leg size. Based on these observations, we discuss possible roles for Gb’mad in the distal patterning and intercalation processes during leg regeneration in Gryllus bimaculatus. | |||||||||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||||||||
| 主題 | Dachsous/Fat | |||||||||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||||||||
| 主題 | decapentaplegic | |||||||||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||||||||
| 主題 | Gryllus bimaculatus | |||||||||||||||||||||||||||||
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| 主題 | intercalation | |||||||||||||||||||||||||||||
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| 主題 | leg regeneration | |||||||||||||||||||||||||||||
| 書誌情報 |
en : Development, Growth & Differentiation 巻 60, 号 6, p. 377-386, 発行日 2018-07-24 |
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| 収録物識別子タイプ | ISSN | |||||||||||||||||||||||||||||
| 収録物識別子 | 1440169X | |||||||||||||||||||||||||||||
| 出版者 | ||||||||||||||||||||||||||||||
| 出版者 | John Wiley & Sons | |||||||||||||||||||||||||||||
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| 出版者 | Japanese Society of Developmental Biologists | |||||||||||||||||||||||||||||
| 権利情報 | ||||||||||||||||||||||||||||||
| 権利情報 | This is the peer reviewed version of the following article: Ishimaru, Y, Bando, T, Ohuchi, H, Noji, S, Mito, T. Bone morphogenetic protein signaling in distal patterning and intercalation during leg regeneration of the cricket, Gryllus bimaculatus. Develop. Growth Differ. 2018; 60: 377– 386., which has been published in final form at https://doi.org/10.1111/dgd.12560. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited. | |||||||||||||||||||||||||||||
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| 識別子 | 343254 | |||||||||||||||||||||||||||||
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| 言語 | eng | |||||||||||||||||||||||||||||
