| Item type |
文献 / Documents(1) |
| 公開日 |
2021-11-17 |
| アクセス権 |
|
|
アクセス権 |
open access |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
関連識別子 |
https://doi.org/10.1084/jem.20201904 |
|
|
関連名称 |
10.1084/jem.20201904 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
The thymoproteasome hardwires the TCR repertoire of CD8+ T cells in the cortex independent of negative selection |
| タイトル別表記 |
|
|
その他のタイトル |
β5t shapes CD8 T cells without negative selection |
| 著者 |
大東, いずみ
Frantzeskakis, Melina
Jacques, Alison
藤森, さゆ美
牛尾, 綾
ヤマシタ, フサノ
石丸, 直澄
Yin, Da
Cam, Margaret
Kelly, Michael C.
Awasthi, Parirokh
髙田, 健介
高浜, 洋介
|
| 抄録 |
|
|
内容記述 |
The thymoproteasome expressed specifically in thymic cortical epithelium optimizes the generation of CD8+ T cells; however, how the thymoproteasome contributes to CD8+ T cell development is unclear. Here, we show that the thymoproteasome shapes the TCR repertoire directly in cortical thymocytes before migration to the thymic medulla. We further show that the thymoproteasome optimizes CD8+ T cell production independent of the thymic medulla; independent of additional antigen-presenting cells, including medullary thymic epithelial cells and dendritic cells; and independent of apoptosis-mediated negative selection. These results indicate that the thymoproteasome hardwires the TCR repertoire of CD8+ T cells with cortical positive selection independent of negative selection in the thymus. |
| 書誌情報 |
en : Journal of Experimental Medicine
巻 218,
号 4,
p. e20201904,
発行日 2021-02-08
|
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
00221007 |
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
15409538 |
| 収録物ID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00697559 |
| 収録物ID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA12119243 |
| 出版者 |
|
|
出版者 |
Rockefeller University Press |
| 権利情報 |
|
|
権利情報 |
This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/licenses/by/4.0/). |
| EID |
|
|
識別子 |
373644 |
| 言語 |
|
|
言語 |
eng |
jem_218_4_e20201904.pdf (5.2 MB)
.png)
