| Item type |
文献 / Documents(1) |
| 公開日 |
2021-11-29 |
| アクセス権 |
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|
アクセス権 |
open access |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
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|
関連識別子 |
https://doi.org/10.3390/nu13020335 |
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関連名称 |
10.3390/nu13020335 |
| 出版タイプ |
|
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出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Association between Vitamin D and Heart Failure Mortality in 10,974 Hospitalized Individuals |
| 著者 |
楠瀬, 賢也
オオクシ, ユウイチロウ
オカヤマ, ヨシヒロ
Zheng, Robert
アベ, ミホ
ナカイ, ミチカズ
スミタ, ヨウコ
伊勢, 孝之
飛梅, 威
山口, 浩司
八木, 秀介
福田, 大受
山田, 博胤
添木, 武
若槻, 哲三
佐田, 政隆
|
| 抄録 |
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内容記述 |
A broad range of chronic conditions, including heart failure (HF), have been associated with vitamin D deficiency. Existing clinical trials involving vitamin D supplementation in chronic HF patients have been inconclusive. We sought to evaluate the outcomes of patients with vitamin D supplementation, compared with a matched cohort using real-world big data of HF hospitalization. This study was based on the Diagnosis Procedure Combination database in the Japanese Registry of All Cardiac and Vascular Datasets (JROAD-DPC). After exclusion criteria, we identified 93,692 patients who were first hospitalized with HF between April 2012 and March 2017 (mean age was 79 ± 12 years, and 52.2% were male). Propensity score (PS) was estimated with logistic regression model, with vitamin D supplementation as the dependent variable and clinically relevant covariates. On PS-matched analysis with 10,974 patients, patients with vitamin D supplementation had lower total in-hospital mortality (6.5 vs. 9.4%, odds ratio: 0.67, p < 0.001) and in-hospital mortality within 7 days and 30 days (0.9 vs. 2.5%, OR, 0.34, and 3.8 vs. 6.5%, OR: 0.56, both p < 0.001). In the sub-group analysis, mortalities in patients with age < 75, diabetes, dyslipidemia, atrial arrhythmia, cancer, renin-angiotensin system blocker, and β-blocker were not affected by vitamin D supplementation. Patients with vitamin D supplementation had a lower in-hospital mortality for HF than patients without vitamin D supplementation in the propensity matched cohort. The identification of specific clinical characteristics in patients benefitting from vitamin D may be useful for determining targets of future randomized control trials. |
| キーワード |
|
|
主題 |
heart failure |
| キーワード |
|
|
主題 |
vitamin D |
| キーワード |
|
|
主題 |
mortality |
| キーワード |
|
|
主題 |
big data |
| 書誌情報 |
en : Nutrients
巻 13,
号 2,
p. 335,
発行日 2021-01-23
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| 収録物ID |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
20726643 |
| 出版者 |
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|
出版者 |
MDPI |
| 権利情報 |
|
|
権利情報 |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
| EID |
|
|
識別子 |
373474 |
| 言語 |
|
|
言語 |
eng |
nu_13_2_335.pdf (946 KB)
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