| アイテムタイプ |
文献 / Documents(1) |
| 公開日 |
2021-12-02 |
| アクセス権 |
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|
アクセス権 |
open access |
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アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 出版社版DOI |
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関連識別子 |
https://doi.org/10.3390/antibiotics9090626 |
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関連名称 |
10.3390/antibiotics9090626 |
| 出版タイプ |
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|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
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|
タイトル |
Clinical Significance of Carbapenem-Tolerant Pseudomonas aeruginosa Isolated in the Respiratory Tract |
| 著者 |
東, 桃代
村上, 圭史
ムラタ, リナ
片岡, 佳子
藤猪, 英樹
三宅, 洋一郎
西岡, 安彦
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| 抄録 |
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内容記述 |
We often come across difficult to treat infections—even after administering appropriate antibiotics according to the minimal inhibitory concentration of the causative bacteria. Antibiotic tolerance has recently started to garner attention as a crucial mechanism of refractory infections. However, few studies have reported the correlation between clinical outcomes and antibiotic tolerance. This study aims to clarify the effect of antibiotic tolerance on clinical outcomes of respiratory tract infection caused by Pseudomonas aeuginosa (P. aeruginosa). We examined a total of 63 strains isolated from sputum samples of different patients and conducted a retrospective survey with the medical records of 37 patients with imipenem-sensitive P. aeruginosa infections. Among them, we selected 15 patients with respiratory infections, and they were divided into high-tolerance minimal bactericidal concentration for adherent bacteria (MBCAD)/minimal inhibitory concentration for adherent bacteria (MICAD) ≥ 32 (n = 9) group and low-tolerance MBCAD/MICAD ≤ 16 (n = 6) group for further investigations. The findings indicated that the high-tolerance group consisted of many cases requiring hospitalization. Chest computed tomography findings showed that the disease was more extensive in the high-tolerance group compared to the low-tolerance group. Regarding the bacterial phenotypic characterization, the high-tolerance group significantly upregulated the production of the virulence factors compared to the low-tolerance group. Our study provided evidence that carbapenem tolerance level is a potent prognostic marker of P. aeruginosa infections, and carbapenem tolerance could be a potential target for new antimicrobial agents to inhibit the progression of persistent P. aeruginosa infections. |
| キーワード |
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|
主題 |
carbapenem tolerance |
| キーワード |
|
|
主題 |
antibiotic tolerance |
| キーワード |
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|
主題 |
Pseudomonas aeruginosa |
| キーワード |
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|
主題 |
respiratory tract infection |
| キーワード |
|
|
主題 |
persistent infections |
| 書誌情報 |
en : Antibiotics
巻 9,
号 9,
p. 626,
発行日 2020-09-21
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| 収録物ID |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
20796382 |
| 出版者 |
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|
出版者 |
MDPI |
| 権利情報 |
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|
権利情報 |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
| EID |
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識別子 |
377437 |
| 言語 |
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|
言語 |
eng |
anti_9_9_626.pdf (2.33 MB)
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