| Item type |
文献 / Documents(1) |
| 公開日 |
2021-12-03 |
| アクセス権 |
|
|
アクセス権 |
open access |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.3390/biom10101468 |
|
|
言語 |
ja |
|
|
関連名称 |
10.3390/biom10101468 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Citrus sudachi Peel Extract Suppresses Cell Proliferation and Promotes the Differentiation of Keratinocytes through Inhibition of the EGFR–ERK Signaling Pathway |
|
言語 |
en |
| 著者 |
アベ, ショウゴ
ウエノ, ミサコ
ニシタニ, マミ
赤松, 徹也
サトウ, タクミ
シモダ, マリエ
カナオカ, ヒロキ
ニイ, ヨシタカ
ヤマサキ, ヒロコ
湯浅, 恵造
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Citrus sudachi is a well-known fruit in Tokushima Prefecture, Japan, and its peels are rich in phytochemicals, including phenolic compounds. Although it is expected that the extract of the C. sudachi peel elicits various beneficial physiological activities, the effect on the skin has not been investigated. In this study, we report that the aqueous extract from the peel of C. sudachi suppresses cell proliferation of the immortalized human keratinocyte cell line, HaCaT, and primary normal human epidermal keratinocytes. The extract of C. sudachi peel suppressed epidermal growth factor (EGF)-induced EGF receptor activation and tumor necrosis factor (TNF)-α-induced extracellular regulated kinase (ERK) 1/2 activation, which suggests that the extract exerts its inhibitory effect through inhibition of both the EGF receptor (EGFR) and its downstream molecules. Additionally, the extract of C. sudachi peel potentiated calcium-induced keratinocyte differentiation. These results suggest that the extract of C. sudachi peel may have beneficial effects against skin diseases that are characterized by hyperproliferation of epidermal keratinocytes, such as those seen in psoriasis and in cutaneous squamous cell carcinoma. |
|
言語 |
en |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
citrus peel extract |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
keratinocyte |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
EGF–EGFR–ERK |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
cell proliferation and differentiation |
| 書誌情報 |
en : Biomolecules
巻 10,
号 10,
p. 1468,
発行日 2020-10-21
|
| 収録物ID |
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|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
2218273X |
| 出版者 |
|
|
出版者 |
MDPI |
|
言語 |
en |
| 権利情報 |
|
|
言語 |
en |
|
権利情報 |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
| EID |
|
|
識別子 |
378258 |
|
識別子タイプ |
URI |
| 言語 |
|
|
言語 |
eng |
biom_10_10_1468.pdf (2.47 MB)
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