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Lysophosphatidic Acid Receptor 1- and 3-Mediated Hyperalgesia and Hypoalgesia in Diabetic Neuropathic Pain Models in Mice
https://tokushima-u.repo.nii.ac.jp/records/2009416
https://tokushima-u.repo.nii.ac.jp/records/20094168a99cd79-5753-45d0-bcad-a6a56ce0d121
| 名前 / ファイル | ライセンス | アクション |
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cells_9_8_1906.pdf (2.29 MB)
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| Item type | 文献 / Documents(1) | |||||||||||||||||||||||
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| 公開日 | 2021-12-07 | |||||||||||||||||||||||
| アクセス権 | ||||||||||||||||||||||||
| アクセス権 | open access | |||||||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||||||||
| 出版社版DOI | ||||||||||||||||||||||||
| 関連識別子 | https://doi.org/10.3390/cells9081906 | |||||||||||||||||||||||
| 関連名称 | 10.3390/cells9081906 | |||||||||||||||||||||||
| 出版タイプ | ||||||||||||||||||||||||
| 出版タイプ | VoR | |||||||||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||||||||
| タイトル | ||||||||||||||||||||||||
| タイトル | Lysophosphatidic Acid Receptor 1- and 3-Mediated Hyperalgesia and Hypoalgesia in Diabetic Neuropathic Pain Models in Mice | |||||||||||||||||||||||
| 著者 |
ウエダ, ヒロシ
× ウエダ, ヒロシ
× ネヤマ, ヒロユキ
× 松下, 洋輔
WEKO
810
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| 内容記述 | Lysophosphatidic acid (LPA) signaling is known to play key roles in the initiation and maintenance of various chronic pain models. Here we examined whether LPA signaling is also involved in diabetes-induced abnormal pain behaviors. The high-fat diet (HFD) showing elevation of blood glucose levels and body weight caused thermal, mechanical hyperalgesia, hypersensitivity to 2000 or 250 Hz electrical-stimulation and hyposensitivity to 5 Hz stimulation to the paw in wild-type (WT) mice. These HFD-induced abnormal pain behaviors and body weight increase, but not elevated glucose levels were abolished in LPA1−/− and LPA3−/− mice. Repeated daily intrathecal (i.t.) treatments with LPA1/3 antagonist AM966 reversed these abnormal pain behaviors. Similar abnormal pain behaviors and their blockade by daily AM966 (i.t.) or twice daily Ki16425, another LPA1/3 antagonist was also observed in db/db mice which show high glucose levels and body weight. Furthermore, streptozotocin-induced similar abnormal pain behaviors, but not elevated glucose levels or body weight loss were abolished in LPA1−/− and LPA3−/− mice. These results suggest that LPA1 and LPA3 play key roles in the development of both type I and type II diabetic neuropathic pain. | |||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||
| 主題 | hypoalgesia | |||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||
| 主題 | lysophosphatidic acid receptor | |||||||||||||||||||||||
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| 主題 | streptozotocin | |||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||
| 主題 | high-fat diet | |||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||
| 主題 | leptin receptor | |||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||
| 主題 | pathogenic | |||||||||||||||||||||||
| 書誌情報 |
en : Cells 巻 9, 号 8, p. 1906, 発行日 2020-08-16 |
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| 収録物識別子タイプ | ISSN | |||||||||||||||||||||||
| 収録物識別子 | 20734409 | |||||||||||||||||||||||
| 出版者 | ||||||||||||||||||||||||
| 出版者 | MDPI | |||||||||||||||||||||||
| 権利情報 | ||||||||||||||||||||||||
| 権利情報 | This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). | |||||||||||||||||||||||
| EID | ||||||||||||||||||||||||
| 識別子 | 379091 | |||||||||||||||||||||||
| 言語 | ||||||||||||||||||||||||
| 言語 | eng | |||||||||||||||||||||||
