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The Cerebellum Is a Common Key for Visuospatial Execution and Attention in Parkinson’s Disease
https://tokushima-u.repo.nii.ac.jp/records/2009422
https://tokushima-u.repo.nii.ac.jp/records/200942247cc26c7-21d5-4aba-89f9-b74d9865ba96
名前 / ファイル | ライセンス | アクション |
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Item type | 文献 / Documents(1) | |||||||||||||||||||||||||||||||||||
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公開日 | 2021-12-13 | |||||||||||||||||||||||||||||||||||
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アクセス権 | open access | |||||||||||||||||||||||||||||||||||
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資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||||||||||||||||||
資源タイプ | journal article | |||||||||||||||||||||||||||||||||||
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関連識別子 | https://doi.org/10.3390/diagnostics11061042 | |||||||||||||||||||||||||||||||||||
関連名称 | 10.3390/diagnostics11061042 | |||||||||||||||||||||||||||||||||||
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出版タイプ | VoR | |||||||||||||||||||||||||||||||||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||||||||||||||||||||
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タイトル | The Cerebellum Is a Common Key for Visuospatial Execution and Attention in Parkinson’s Disease | |||||||||||||||||||||||||||||||||||
著者 |
佐光, 亘
× 佐光, 亘× 阿部, 考志× 松元, 友暉
WEKO
892
× ナカムラ, カズミ
× 土師, 正太郎
× 大崎, 裕亮× 原田, 雅史
WEKO
1589
× 和泉, 唯信
WEKO
1623
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内容記述 | Cognitive decline affects the clinical course in patients with Parkinson’s disease (PD) and contributes to a poor prognosis. However, little is known about the underlying network-level abnormalities associated with each cognitive domain. We aimed to identify the networks related to each cognitive domain in PD using resting-state functional magnetic resonance imaging (MRI). Forty patients with PD and 15 normal controls were enrolled. All subjects underwent MRI and the Mini-Mental State Examination. Furthermore, the cognitive function of patients with PD was assessed using the Montreal Cognitive Assessment (MoCA). We used independent component analysis of the resting-state functional MRI for functional segmentation, followed by reconstruction to identify each domain-related network, to predict scores in PD using multiple regression models. Six networks were identified, as follows: the visuospatial-executive-domain-related network (R2 = 0.54, p < 0.001), naming-domain-related network (R2 = 0.39, p < 0.001), attention-domain-related network (R2 = 0.86, p < 0.001), language-domain-related network (R2 = 0.64, p < 0.001), abstraction-related network (R2 = 0.10, p < 0.05), and orientation-domain-related network (R2 = 0.64, p < 0.001). Cerebellar lobule VII was involved in the visuospatial-executive-domain-related and attention-domain-related networks. These two domains are involved in the first three listed nonamnestic cognitive impairment in the diagnostic criteria for PD with dementia (PDD). Furthermore, Brodmann area 10 contributed most frequently to each domain-related network. Collectively, these findings suggest that cerebellar lobule VII may play a key role in cognitive impairment in nonamnestic types of PDD. | |||||||||||||||||||||||||||||||||||
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主題 | Parkinson’s disease | |||||||||||||||||||||||||||||||||||
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主題 | cognition | |||||||||||||||||||||||||||||||||||
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主題 | functional MRI | |||||||||||||||||||||||||||||||||||
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主題 | network | |||||||||||||||||||||||||||||||||||
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主題 | cerebellum | |||||||||||||||||||||||||||||||||||
書誌情報 |
en : Diagnostics 巻 11, 号 6, p. 1042, 発行日 2021-06-06 |
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収録物識別子タイプ | ISSN | |||||||||||||||||||||||||||||||||||
収録物識別子 | 20754418 | |||||||||||||||||||||||||||||||||||
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出版者 | MDPI | |||||||||||||||||||||||||||||||||||
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権利情報 | This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). | |||||||||||||||||||||||||||||||||||
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識別子 | 386036 | |||||||||||||||||||||||||||||||||||
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言語 | eng |