| Item type |
文献 / Documents(1) |
| 公開日 |
2021-12-03 |
| アクセス権 |
|
|
アクセス権 |
open access |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.2152/jmi.68.362 |
|
|
言語 |
ja |
|
|
関連名称 |
10.2152/jmi.68.362 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Impact of CKLF-like MARVEL transmembrane domain containing 6 (CMTM6) expression in gastric cancer |
|
言語 |
en |
| タイトル別表記 |
|
|
その他のタイトル |
CMTM6 is a Prognostic Factor in GC |
|
言語 |
en |
| 著者 |
西, 正暁
島田, 光生
吉川, 幸造
東島, 潤
徳永, 卓哉
柏原, 秀也
髙須, 千絵
江藤, 祥平
良元, 俊昭
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Background : CKLF-like MARVEL transmembrane domain containing 6 (CMTM6) is the master regulator of programmed cell death-ligand 1 (PD-L1). We aimed to clarify the significance of CMTM6 expression in gastric cancer (GC). Methods : A total of 105 patients who had undergone curative surgical resection for stage II / III GC at Tokushima University Hospital were included in this study. The expression of CMTM6 was examined by immunohistochemistry. Additionally, the relationship of each expression level to several prognostic factors was examined using univariate and multivariate analyses. Results : CMTM6 was not positively correlated with any of the factors examined. The overall survival (OS) rates were significantly poorer in the CMTM6 high-expression group than in the CMTM low-expression group (5-year OS : 57.2% vs. 79.2%, respectively ; p < 0.05). Disease-free survival (DFS) was significantly poorer in the CMTM high-expression group than in the CMTM6 low-expression group (5-year DFS : 52.8% vs. 72.4%, respectively ; p < 0.05). Multivariate analysis confirmed CMTM6 expression as an independent prognostic factor in DFS (p < 0.05). CMTM6 expression tended to be correlated with PD-L1 expression (p = 0.07). Conclusions : CMTM6 is associated with a poor prognosis and immunotolerance through PD-L1 in GC. |
|
言語 |
en |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Gastric cancer |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
CMTM6 |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
PD-L1 |
| 書誌情報 |
en : The Journal of Medical Investigation
巻 68,
号 3-4,
p. 362-367,
発行日 2021-08
|
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
13496867 |
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
13431420 |
| 収録物ID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA11166929 |
| 出版者 |
|
|
出版者 |
Tokushima University Faculty of Medicine |
|
言語 |
en |
| EID |
|
|
識別子 |
386700 |
|
識別子タイプ |
URI |
| 言語 |
|
|
言語 |
eng |
jmi_68_3-4_362.pdf (540 KB)
