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Upper limb muscle atrophy associated with in-hospital mortality and physical function impairments in mechanically ventilated critically ill adults : a two-center prospective observational study

https://tokushima-u.repo.nii.ac.jp/records/2009455
https://tokushima-u.repo.nii.ac.jp/records/2009455
ab2d58f1-dd9c-462a-91f9-97c81d69300a
名前 / ファイル ライセンス アクション
jintcare_8_87.pdf jintcare_8_87.pdf (684 KB)
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Item type 文献 / Documents(1)
公開日 2022-01-14
アクセス権
アクセス権 open access
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
出版社版DOI
関連識別子 https://doi.org/10.1186/s40560-020-00507-7
関連名称 10.1186/s40560-020-00507-7
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
タイトル
タイトル Upper limb muscle atrophy associated with in-hospital mortality and physical function impairments in mechanically ventilated critically ill adults : a two-center prospective observational study
著者 中西, 信人

× 中西, 信人

ja 中西, 信人

ja-Kana ナカニシ, ノブト

en Nakanishi, Nobuto

Search repository
大藤, 純

× 大藤, 純

WEKO 1193
徳島大学 教育研究者総覧 60684/profile-ja.html
e-Rad 40346606

ja 大藤, 純
ISNI

ja-Kana オオトウ, ジュン

en Oto, Jun

Search repository
堤, 理恵

× 堤, 理恵

WEKO 428
徳島大学 教育研究者総覧 207524/profile-ja.html
e-Rad 80510172

ja 堤, 理恵
ISNI

ja-Kana ツツミ, リエ

en Tsutsumi, Rie

Search repository
秋本, 雄祐

× 秋本, 雄祐

ja 秋本, 雄祐

ja-Kana アキモト, ユウスケ

en Akimoto, Yusuke

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ナカノ, ユウキ

× ナカノ, ユウキ

ja ナカノ, ユウキ

ja-Kana ナカノ, ユウキ

en Nakano, Yuki

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西村, 匡司

× 西村, 匡司

WEKO 1227
徳島大学 教育研究者総覧 77950/profile-ja.html
e-Rad 10172701

ja 西村, 匡司
ISNI

ja-Kana ニシムラ, マサジ

en Nishimura, Masaji

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抄録
内容記述 Background: Lower limb muscle atrophy is often observed in critically ill patients. Although upper limb muscles can undergo atrophy, it remains unclear how this atrophy is associated with clinical outcomes. We hypothesized that this atrophy is associated with mortality and impairments in physical function.
Methods: In this two-center prospective observational study, we included adult patients who were expected to require mechanical ventilation for > 48 h and remain in the intensive care unit (ICU) for > 5 days. We used ultrasound to evaluate the cross-sectional area of the biceps brachii on days 1, 3, 5, and 7 and upon ICU discharge along with assessment of physical functions. The primary outcome was the relationship between muscle atrophy ratio and in-hospital mortality on each measurement day, which was assessed using multivariate analysis. The secondary outcomes were the relationships between upper limb muscle atrophy and Medical Research Council (MRC) score, handgrip strength, ICU Mobility Scale (IMS) score, and Functional Status Score for the ICU (FSS-ICU).
Results: Sixty-four patients (43 males; aged 70 ± 13 years) were enrolled. The Acute Physiology and Chronic Health Evaluation (APACHE) II score was 27 (22–30), and in-hospital mortality occurred in 21 (33%) patients. The decreased cross-sectional area of the biceps brachii was not associated with in-hospital mortality on day 3 (p = 0.43) but was associated on days 5 (p = 0.01) and 7 (p < 0.01), which was confirmed after adjusting for sex, age, and APACHE II score. In 27 patients in whom physical functions were assessed, the decrease of the cross-sectional area of the biceps brachii was associated with MRC score (r = 0.47, p = 0.01), handgrip strength (r = 0.50, p = 0.01), and FSS-ICU (r = 0.56, p < 0.01), but not with IMS score (r = 0.35, p = 0.07) upon ICU discharge.
Conclusions: Upper limb muscle atrophy was associated with in-hospital mortality and physical function impairments; thus, it is prudent to monitor it.
キーワード
主題 Muscle atrophy
キーワード
主題 Upper limb
キーワード
主題 In-hospital mortality
キーワード
主題 Critically ill patients
キーワード
主題 Ultrasonography
書誌情報 en : Journal of Intensive Care

巻 8, p. 87, 発行日 2020-11-23
収録物ID
収録物識別子タイプ ISSN
収録物識別子 20520492
出版者
出版者 BioMed Central
出版者
出版者 Springer Nature
権利情報
権利情報 This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
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識別子 381134
言語
言語 eng
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