| Item type |
文献 / Documents(1) |
| 公開日 |
2022-01-17 |
| アクセス権 |
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|
アクセス権 |
open access |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
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|
関連識別子 |
https://doi.org/10.1016/j.jmbbm.2020.103744 |
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|
関連名称 |
10.1016/j.jmbbm.2020.103744 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Ultra-high-purity iron is a novel and very compatible biomaterial |
| 著者 |
Khan, Luqman
サトウ, カツミ
オクヤマ, シンイチ
コバヤシ, タケシ
オオハシ, カズマサ
平坂, 勝也
二川, 健
タカダ, クニオ
ヒガシタニ, アツシ
アビコ, ケンジ
|
| 抄録 |
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|
内容記述 |
Metals and alloys are used widely in bone prosthetic materials, stents and dental tissue reconstructions. The most common materials are stainless steels and cobalt-chromium-nickel and titanium alloys. These alloys can be easily deformed but are hard to break. However, their affinity for cells and tissues is very low. In addition, they can sometimes provoke unexpected metal allergies. Iron is an abundant trace element essential for humans. However, excess amounts in particular of Fe2+ ions are toxic. We previously succeeded in obtaining 99.9996% ultra-high-purity iron (ABIKO iron). The chemical properties of ABIKO iron are completely different from that of conventional pure iron. For example, the reaction rate in hydrochloric acid is very slow and there is barely any corrosion. Here, we found that, in the absence of any type of coating, mammalian cells could easily attach to, and normally proliferate and differentiate on, ABIKO iron. On the other hand, cell densities and proliferation rate of the surfaces of plates made from Co–Cr–Mo or Ti–6Al–4V were significantly reduced. In addition, several stress and iron response genes, HSP70, SOD1, ATM and IRP2 did not change in the cells on ABIKO iron, while these genes were induced with exogenous application of FeSO4. Cells also secreted and fastened some organics on ABIKO iron. In vitro collagen binding assay showed that ABIKO iron binds higher amount of collagens. These findings highlight ABIKO iron as a novel biocompatible prosthetic material. |
| キーワード |
|
|
主題 |
Cell differentiation |
| キーワード |
|
|
主題 |
Cell proliferation |
| キーワード |
|
|
主題 |
Fe |
| キーワード |
|
|
主題 |
Mesenchymal stem cells |
| キーワード |
|
|
主題 |
Myoblast |
| 書誌情報 |
en : Journal of the Mechanical Behavior of Biomedical Materials
巻 106,
p. 103744,
発行日 2020-03-27
|
| 収録物ID |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
17516161 |
| 収録物ID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA12344261 |
| 出版者 |
|
|
出版者 |
Elsevier |
| 権利情報 |
|
|
権利情報 |
This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
| EID |
|
|
識別子 |
378519 |
| 言語 |
|
|
言語 |
eng |
jmbbm_106_103744.pdf (3.46 MB)
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