| Item type |
文献 / Documents(1) |
| 公開日 |
2022-01-20 |
| アクセス権 |
|
|
アクセス権 |
open access |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
関連識別子 |
https://doi.org/10.26508/lsa.202000960 |
|
|
関連名称 |
10.26508/lsa.202000960 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Cell-autonomous Toxoplasma killing program requires Irgm2 but not its microbe vacuolar localization |
| タイトル別表記 |
|
|
その他のタイトル |
Role of Irgm2 in anti-Toxoplasma immunity |
| 著者 |
Pradipta, Ariel
ササイ, ミワ
茂谷, 康
Ma, Ji Su
Lee, Youngae
小迫, 英尊
ヤマモト, マサヒロ
|
| 抄録 |
|
|
内容記述 |
Interferon-inducible GTPases, such as immunity-related GTPases (IRGs) and guanylate-binding proteins (GBPs), are essential for cell-autonomous immunity against a wide variety of intracellular pathogens including Toxoplasma. IRGs comprise regulatory and effector subfamily proteins. Regulatory IRGs Irgm1 and Irgm3 play important roles in anti-Toxoplasma immunity by globally controlling effector IRGs and GBPs. There is a remaining regulatory IRG, called Irgm2, which highly accumulates on parasitophorous vacuole membranes (PVMs). Very little is known about the mechanism of the unique localization on Toxoplasma PVMs. Here, we show that Irgm2 is important to control parasite killing through recruitment of Gbp1 and Irgb6, which does not require Irgm2 localization at Toxoplasma PVMs. Ubiquitination of Irgm2 in the cytosol, but not at the PVM, is also important for parasite killing through recruitment of Gbp1 to the PVM. Conversely, PVM ubiquitination and p62/Sqstm1 loading at later time points post-Toxoplasma infection require Irgm2 localization at the PVM. Irgm2-deficient mice are highly susceptible to Toxoplasma infection. Taken together, these data indicate that Irgm2 selectively controls accumulation of anti-Toxoplasma effectors to the vacuole in a manner dependent or independent on Irgm2 localization at the Toxoplasma PVM, which mediates parasite killing. |
| 書誌情報 |
en : Life Science Alliance
巻 4,
号 7,
p. e202000960,
発行日 2021-06-02
|
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
25751077 |
| 出版者 |
|
|
出版者 |
Life Science Alliance |
| 権利情報 |
|
|
権利情報 |
This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/licenses/by/4.0/). |
| EID |
|
|
識別子 |
376495 |
| 言語 |
|
|
言語 |
eng |
lsa_4_7_e202000960.pdf (2.91 MB)
.png)
