| Item type |
文献 / Documents(1) |
| 公開日 |
2022-01-28 |
| アクセス権 |
|
|
アクセス権 |
open access |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.3390/metabo10110442 |
|
|
言語 |
ja |
|
|
関連名称 |
10.3390/metabo10110442 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Comprehensive Dipeptide Analysis Revealed Cancer-Specific Profile in the Liver of Patients with Hepatocellular Carcinoma and Hepatitis |
|
言語 |
en |
| 著者 |
オザワ, ヒトシ
ヒラヤマ, アキヨシ
ショウジ, フタバ
マルヤマ, ミドリ
スズキ, クミ
(山中)奥村, 仙示
タタノ, ヒロシ
森根, 裕二
ソガ, トモヨシ
島田, 光生
トミタ, マサル
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
As the physical properties and functionality of dipeptides differ from those of amino acids, they have attracted attention in metabolomics; however, their functions in vivo have not been clarified in detail. Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer, and its major cause is chronic hepatitis. This study was conducted to explore tumor-specific dipeptide characteristics by performing comprehensive dipeptide analysis in the tumor and surrounding nontumor tissue of patients with HCC. Dipeptides were analyzed by liquid chromatography tandem mass spectrometry and capillary electrophoresis tandem mass spectrometry. Principal component analysis using 236 detected dipeptides showed differences in the dipeptide profiles between nontumor and tumor tissues; however, no clear difference was observed in etiological comparison. In addition, the N- and C-terminal amino acid compositions of the detected dipeptides significantly differed, suggesting the substrate specificity of enzyme proteins, such as peptidase. Furthermore, hepatitis-derived HCC may show a characteristic dipeptide profile even before tumor formation. These results provide insight into HCC pathogenesis and may help identify novel biomarkers for diagnosis. |
|
言語 |
en |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
dipeptide |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
hepatocellular carcinoma |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
hepatitis B virus |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
hepatitis C virus |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
liquid chromatography tandem mass spectrometry |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
capillary electrophoresis tandem mass spectrometry |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
metabolomics |
| 書誌情報 |
en : Metabolites
巻 10,
号 11,
p. 442,
発行日 2020-11-01
|
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
22181989 |
| 出版者 |
|
|
出版者 |
MDPI |
|
言語 |
en |
| 権利情報 |
|
|
言語 |
en |
|
権利情報 |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
| EID |
|
|
識別子 |
376983 |
|
識別子タイプ |
URI |
| 言語 |
|
|
言語 |
eng |
metabo_10_11_442.pdf (1.14 MB)
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