| アイテムタイプ |
文献 / Documents(1) |
| 公開日 |
2022-01-28 |
| アクセス権 |
|
|
アクセス権 |
open access |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
関連識別子 |
https://doi.org/10.1186/s13041-020-0547-z |
|
|
関連名称 |
10.1186/s13041-020-0547-z |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Pcdhβ deficiency affects hippocampal CA1 ensemble activity and contextual fear discrimination |
| 著者 |
アサイ, ヒロタカ
オオカワ, ノリアキ
サイトウ, ヨシト
Ghandour, Khaled
ムラヤマ, エミ
ニシゾノ, ヒロフミ
マツオ, ミナ
平山, 晃斉
カネコ, リョウスケ
ムラマツ, シンイチ
ヤギ, タケシ
イノクチ, カオル
|
| 抄録 |
|
|
内容記述 |
Clustered protocadherins (Pcdhs), a large group of adhesion molecules, are important for axonal projections and dendritic spread, but little is known about how they influence neuronal activity. The Pcdhβ cluster is strongly expressed in the hippocampus, and in vivo Ca2+ imaging in Pcdhβ-deficient mice revealed altered activity of neuronal ensembles but not of individual cells in this region in freely moving animals. Specifically, Pcdhβ deficiency increased the number of large-size neuronal ensembles and the proportion of cells shared between ensembles. Furthermore, Pcdhβ-deficient mice exhibited reduced repetitive neuronal population activity during exploration of a novel context and were less able to discriminate contexts in a contextual fear conditioning paradigm. These results suggest that one function of Pcdhβs is to modulate neural ensemble activity in the hippocampus to promote context discrimination. |
| キーワード |
|
|
主題 |
Hippocampus |
| キーワード |
|
|
主題 |
CA1 |
| キーワード |
|
|
主題 |
Clustered protocadherin |
| キーワード |
|
|
主題 |
Pcdhβ |
| キーワード |
|
|
主題 |
Ca2+ imaging |
| キーワード |
|
|
主題 |
Ensemble |
| キーワード |
|
|
主題 |
Contextual fear memory |
| キーワード |
|
|
主題 |
Discrimination |
| 書誌情報 |
en : Molecular Brain
巻 13,
p. 7,
発行日 2020-01-20
|
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
17566606 |
| 出版者 |
|
|
出版者 |
BioMed Central |
| 出版者 |
|
|
出版者 |
Springer Nature |
| 権利情報 |
|
|
権利情報 |
This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
| EID |
|
|
識別子 |
380813 |
| 言語 |
|
|
言語 |
eng |
mb_13_7.pdf (1.5 MB)
.png)
