| Item type |
文献 / Documents(1) |
| 公開日 |
2022-01-28 |
| アクセス権 |
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|
アクセス権 |
open access |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 出版社版DOI |
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|
関連識別子 |
https://doi.org/10.3390/nano11071697 |
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|
関連名称 |
10.3390/nano11071697 |
| 出版タイプ |
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|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Doxorubicin Embedded into Nanofibrillated Bacterial Cellulose (NFBC) Produces a Promising Therapeutic Outcome for Peritoneally Metastatic Gastric Cancer in Mice Models via Intraperitoneal Direct Injection |
| 著者 |
安藤, 英紀
モチヅキ, タカシ
Lila, Amr S. Abu
アカギ, シュンスケ
タジマ, ケンジ
フジタ, ケンジ
清水, 太郎
異島, 優
マツシマ, トクオ
クサノ, タカトモ
石田, 竜弘
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| 抄録 |
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内容記述 |
Natural materials such as bacterial cellulose are gaining interest for their use as drug-delivery vehicles. Herein, the utility of nanofibrillated bacterial cellulose (NFBC), which is produced by culturing a cellulose-producing bacterium (Gluconacetobacter intermedius NEDO-01) in a medium supplemented with carboxymethylcellulose (CMC) that is referred to as CM-NFBC, is described. Recently, we demonstrated that intraperitoneal administration of paclitaxel (PTX)-containing CM-NFBC efficiently suppressed tumor growth in a peritoneally disseminated cancer xenograft model. In this study, to confirm the applicability of NFBC in cancer therapy, a chemotherapeutic agent, doxorubicin (DXR), embedded into CM-NFBC, was examined for its efficiency to treat a peritoneally disseminated gastric cancer via intraperitoneal administration. DXR was efficiently embedded into CM-NFBC (DXR/CM-NFBC). In an in vitro release experiment, 79.5% of DXR was released linearly into the peritoneal wash fluid over a period of 24 h. In the peritoneally disseminated gastric cancer xenograft model, intraperitoneal administration of DXR/CM-NFBC induced superior tumor growth inhibition (TGI = 85.5%) by day 35 post-tumor inoculation, compared to free DXR (TGI = 62.4%). In addition, compared with free DXR, the severe side effects that cause body weight loss were lessened via treatment with DXR/CM-NFBC. These results support the feasibility of CM-NFBC as a drug-delivery vehicle for various anticancer agents. This approach may lead to improved therapeutic outcomes for the treatment of intraperitoneally disseminated cancers. |
| キーワード |
|
|
主題 |
nanofibrillated bacterial cellulose |
| キーワード |
|
|
主題 |
bacterial cellulose |
| キーワード |
|
|
主題 |
peritoneally disseminated gastric cancer |
| キーワード |
|
|
主題 |
doxorubicin |
| キーワード |
|
|
主題 |
intraperitoneal chemotherapy |
| 書誌情報 |
en : Nanomaterials
巻 11,
号 7,
p. 1697,
発行日 2021-06-28
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| 収録物ID |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
20794991 |
| 出版者 |
|
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出版者 |
MDPI |
| 権利情報 |
|
|
権利情報 |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
| EID |
|
|
識別子 |
376567 |
| 言語 |
|
|
言語 |
eng |
nano_11_7_1697.pdf (1.3 MB)
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