| Item type |
文献 / Documents(1) |
| 公開日 |
2022-01-28 |
| アクセス権 |
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|
アクセス権 |
open access |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
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|
|
関連識別子 |
https://doi.org/10.18632/oncotarget.27852 |
|
|
関連名称 |
10.18632/oncotarget.27852 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Reduction of T-Box 15 gene expression in tumor tissue is a prognostic biomarker for patients with hepatocellular carcinoma |
| 著者 |
森根, 裕二
宇都宮, 徹
齋藤, 裕
山田, 眞一郎
居村, 暁
池本, 哲也
キタガワ, アキヒロ
コバヤシ, ユウタ
タカオ, セイイチロウ
コサイ, ケイスケ
ミモリ, コオシ
タナカ, ヤスヒト
島田, 光生
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| 抄録 |
|
|
内容記述 |
Genome-wide analysis is widely applied to detect molecular alterations during oncogenesis and tumor progression. We analyzed DNA methylation profiles of hepatocellular carcinoma (HCC), and investigated the clinical role of most heypermethylated of tumor, encodes T-box 15 (TBX15), which was originally involved in mesodermal differentiation. We conducted a genome-wide analysis of DNA methylation of tumor and non-tumor tissue of 15 patients with HCC, and revealed TBX15 was the most hypermethylated gene of tumor (Beta-value in tumor tissue = 0.52 compared with non-tumor tissue). Another validation set, which comprised 58 HCC with radical resection, was analyzed to investigate the relationships between tumor phenotype and TBX15 mRNA expression. TBX15 mRNA levels in tumor tissues were significantly lower compared with those of nontumor tissues (p < 0.0001). When we assigned a cutoff value = 0.5-fold, the overall survival 5-year survival rates of the low-expression group (n = 17) were significantly shorter compared with those of the high-expression group (n = 41) (43.3% vs. 86.2%, p = 0.001). Multivariate analysis identified low TBX15 expression as an independent prognostic factor for overall and disease-free survival. Therefore, genome-wide DNA methylation profiling indicates that hypermethylation and reduced expression of TBX15 in tumor tissue represents a potential biomarker for predicting poor survival of patients with HCC. |
| キーワード |
|
|
主題 |
genome-wide analysis |
| キーワード |
|
|
主題 |
methylation |
| キーワード |
|
|
主題 |
tumor suppressor gene |
| キーワード |
|
|
主題 |
prognostic biomarker |
| キーワード |
|
|
主題 |
hepatocellular carcinoma |
| 書誌情報 |
en : Oncotarget
巻 11,
号 52,
p. 4803-4812,
発行日 2020-12-29
|
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
19492553 |
| 出版者 |
|
|
出版者 |
Impact Journals |
| 権利情報 |
|
|
権利情報 |
This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
| EID |
|
|
識別子 |
376981 |
| 言語 |
|
|
言語 |
eng |
onc_11_52_4803.pdf (1.93 MB)
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