| Item type |
文献 / Documents(1) |
| 公開日 |
2022-02-01 |
| アクセス権 |
|
|
アクセス権 |
open access |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1371/journal.pone.0241290 |
|
|
言語 |
ja |
|
|
関連名称 |
10.1371/journal.pone.0241290 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Bioactivity of alginetin, a caramelization product of pectin : Cytometric analysis of rat thymic lymphocytes using fluorescent probes |
|
言語 |
en |
| タイトル別表記 |
|
|
その他のタイトル |
Biological interaction of alginetin |
|
言語 |
en |
| 著者 |
ドイ, サヤカ
カワムラ, ミナ
オヤマ, ケイスケ
赤松, 徹也
ミゾブチ, ミズキ
小山, 保夫
増田, 俊哉
亀村, 典生
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Alginetin is the major product formed from pentoses and hexurionic acids. Alginetin is producted by cooking process of food including pection, a naturally-occurring polysacharride found in many plants. However, the biological interaction and toxicity of alginetin are not known at all. The aim of the present study was to investigate the cellular actions of alginetin on rat thymic lymphocytes. The effects of alginetin on the cell were examined using flow cytometry with fluorescent probes. Alginetin increased cellular content of non-protein thiols ([NPT]i) and elevated intracellular Zn2+ levels ([Zn2+]i). Chelation of intracellular Zn2+ reduced the effect of alginetin on [NPT]i, and chelation of external Zn2+ almost completely diminished alginetin-induced elevation of [Zn2+]i, indicating that alginetin treatment increased Zn2+ influx. Increased [NPT]i and [Zn2+]i levels in response to alginetin were positively correlated. Alginetin protected cells against oxidative stress induced by hydrogen peroxide and Ca2+ overload by calcium ionophore. It is considered that the increases in [NPT]i and [Zn2+]i are responsible for the cytoprotective activity of alginetin because NPT attenuates oxidative stress and Zn2+ competes with Ca2+. Alginetin may be produced during manufacturing of jam, which may provide additional health benefits of jam. |
|
言語 |
en |
| 書誌情報 |
en : PLOS ONE
巻 15,
号 11,
p. e0241290,
発行日 2020-11-02
|
| 収録物ID |
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|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
19326203 |
| 出版者 |
|
|
出版者 |
PLOS |
|
言語 |
en |
| 権利情報 |
|
|
言語 |
en |
|
権利情報 |
This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
| EID |
|
|
識別子 |
378259 |
|
識別子タイプ |
URI |
| 言語 |
|
|
言語 |
eng |
pone_15_11_e0241290.pdf (1.98 MB)
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