| Item type |
文献 / Documents(1) |
| 公開日 |
2022-02-03 |
| アクセス権 |
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|
アクセス権 |
open access |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
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|
識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.1371/journal.pone.0237104 |
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言語 |
ja |
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|
関連名称 |
10.1371/journal.pone.0237104 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Iron deposition in autopsied liver specimens from older patients receiving intravenous iron infusion |
|
言語 |
en |
| タイトル別表記 |
|
|
その他のタイトル |
Iron deposition in autopsied liver on patients receiving long-term TPN |
|
言語 |
en |
| 著者 |
アカツ, ヒロヤス
マナベ, トシエ
カワデ, ヨシヒロ
タナカ, ハジメ
カネマツ, タカヨシ
アラカワ, カズユキ
マサキ, ヨシユキ
ヒシダ, チエ
カネサカ, タケシ
オガワ, ノリヒロ
ハシヅメ, ヨシオ
常山, 幸一
オハラ, ヒロタカ
マルヤマ, ミツオ
ヤマモト, タカユキ
|
| 抄録 |
|
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内容記述タイプ |
Abstract |
|
内容記述 |
Background
Vitamins and minerals are routinely administered by total parenteral nutrition (TPN). However, in Japan, adjustments in iron dosage are difficult because blended mineral preparations are often used. It is therefore unclear whether the iron content is appropriate in cases of long-term TPN. The aim of the study was to assess the influence of iron administration by long-term TPN on iron deposition in post-mortem liver samples isolated from older deceased patients.
Methods
Liver tissues were collected from post-mortem autopsies of 187 patients over a period of 15 years. Samples were stained with Prussian blue and histologically evaluated from Grade 0–V by at least three different observers. Specimens with positive and negative iron staining were compared, and positive samples were grouped according to the level and distribution of the staining. Post-mortem blood obtained from the subclavian vein during autopsy was also analysed. Samples were collected for the measurement of unsaturated serum iron, serum iron, albumin, prealbumin, hepcidin, and IL-6 concentrations.
Results
Iron accumulation in the liver was significantly higher in male patients (p = 0.005) with a history of surgery (p = 0.044) or central vein administration of iron (p<0.001). Additionally, the duration of TPN in the iron-positive group was significantly longer than in the iron-negative group (p = 0.038). Serum analysis revealed that unsaturated serum iron was significantly higher in the iron-negative group and that ferritin and serum iron were significantly higher in the iron-positive group. No other statistically significant differences were observed between the two groups.
Conclusions
Chronic intravenous administration of iron was associated with iron deposition in the liver, even when given the minimum recommended dosage. In long-term TPN patients, the iron dose should therefore be carefully considered. |
|
言語 |
en |
| 書誌情報 |
en : PLOS ONE
巻 15,
号 8,
p. e0237104,
発行日 2020-08-04
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| 収録物ID |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
19326203 |
| 出版者 |
|
|
出版者 |
PLOS |
|
言語 |
en |
| 権利情報 |
|
|
言語 |
en |
|
権利情報 |
This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
| EID |
|
|
識別子 |
380922 |
|
識別子タイプ |
URI |
| 言語 |
|
|
言語 |
eng |
pone_15_8_e0237104.pdf (1.16 MB)
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