| Item type |
文献 / Documents(1) |
| 公開日 |
2022-01-26 |
| アクセス権 |
|
|
アクセス権 |
open access |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
関連識別子 |
https://doi.org/10.7554/eLife.69088 |
|
|
関連名称 |
10.7554/eLife.69088 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Fine-tuning of β-catenin in mouse thymic epithelial cells is required for postnatal T-cell development |
| 著者 |
藤森, さゆ美
大東, いずみ
アベ, ハヤト
松下, 洋輔
片桐, 豊雅
タケト, マコト
高浜, 洋介
タカダ, シンジ
|
| 抄録 |
|
|
内容記述 |
In the thymus, the thymic epithelium provides a microenvironment essential for the development of functionally competent and self-tolerant T cells. Previous findings showed that modulation of Wnt/β-catenin signaling in mouse thymic epithelial cells (TECs) disrupts embryonic thymus organogenesis. However, the role of β-catenin in TECs for postnatal T-cell development remains to be elucidated. Here, we analyzed gain-of-function (GOF) and loss-of-function (LOF) of β-catenin highly specific in mouse TECs. We found that GOF of β-catenin in TECs results in severe thymic dysplasia and T-cell deficiency beginning from the embryonic period. By contrast, LOF of β-catenin in TECs reduces the number of cortical TECs and thymocytes modestly and only postnatally. These results indicate that fine-tuning of β-catenin expression within a permissive range is required for TECs to generate an optimal microenvironment to support postnatal T-cell development. |
| 書誌情報 |
en : eLife
巻 11,
p. e69088,
発行日 2022-01-19
|
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
2050084X |
| 出版者 |
|
|
出版者 |
eLife Sciences Publications |
| 権利情報 |
|
|
権利情報 |
This is an open-access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication (https://creativecommons.org/publicdomain/zero/1.0/). |
| EID |
|
|
識別子 |
383730 |
| 言語 |
|
|
言語 |
eng |
elife_11_e69088.pdf (18.4 MB)
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