| Item type |
文献 / Documents(1) |
| 公開日 |
2022-02-24 |
| アクセス権 |
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アクセス権 |
open access |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 出版社版DOI |
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関連識別子 |
https://doi.org/10.1038/s41598-020-79377-w |
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関連名称 |
10.1038/s41598-020-79377-w |
| 出版タイプ |
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|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
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|
タイトル |
Incidence of endophthalmitis after intravitreal injection of an anti-VEGF agent with or without topical antibiotics |
| 著者 |
モリオカ, マサカズ
タカムラ, ヨシヒロ
ナガイ, カズキ
ヨシダ, シゲオ
モリ, ジュンヤ
タケウチ, マサル
サワダ, トモコ
ソネ, クミコ
フクヤマ, ヒサシ
クスハラ, センタロウ
ヤスカワ, ツトム
ムラカミ, トモヤ
タブチ, ヒトシ
ナガサト, ダイスケ
ヒラノ, タカオ
ウエダ, テツオ
ジュウジョウ, タツヤ
ササジマ, ヒロフミ
三田村, 佳典
イシカワ, クニヒロ
イナタニ, マサル
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| 抄録 |
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内容記述 |
Intravitreal injection (IVI) of anti-vascular endothelial growth factor (VEGF) is the standard treatment modality in various types of retinal diseases. However, endophthalmitis remains the most serious complication. Despite the lack of evidence that antibiotics prevent endophthalmitis, topical antibiotics are still used routinely in Japan. We conducted a retrospective multicenter study by analyzing records from patients who underwent IVI of anti-VEGF agents with or without antibiotic treatment. In the analysis of a total of 147,440 eyes, the incidence of endophthalmitis was 0.007%: 0.005% with no use of antibiotics, 0.009% with antibiotic pretreatment, 0.012% with posttreatment, and 0.005% with pre- and posttreatment. There was no statistically significant difference among the four groups (chi-square test, p = 0.57). Most facilities used masks, sterilized gloves, and drapes. Nine of the 10 eyes that developed endophthalmitis received topical antibiotics, and all infected eyes underwent IVI with aflibercept, not the prefilled syringe delivery system. In four patients who received multiple IVI, the detection of causative bacteria revealed resistance to used antibiotics. Data from this large population, treated with or without antibiotics, suggests that antibiotic prophylaxis does not reduce the rate of endophthalmitis after IVI. |
| 書誌情報 |
en : Scientific Reports
巻 10,
p. 22122,
発行日 2020-12-17
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| 収録物ID |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
20452322 |
| 出版者 |
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出版者 |
Springer Nature |
| 権利情報 |
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|
権利情報 |
This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
| EID |
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|
識別子 |
377011 |
| 言語 |
|
|
言語 |
eng |
srep_10_22122.pdf (861 KB)
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