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Current status of the application of gene editing in pigs
https://tokushima-u.repo.nii.ac.jp/records/2009572
https://tokushima-u.repo.nii.ac.jp/records/20095724783fc8a-eb33-42db-90a8-11f360feadcf
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
jrd_67_3_177.pdf (1.23 MB)
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| Item type | 文献 / Documents(1) | |||||||||||
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| 公開日 | 2022-03-02 | |||||||||||
| アクセス権 | ||||||||||||
| アクセス権 | open access | |||||||||||
| 資源タイプ | ||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||
| 資源タイプ | journal article | |||||||||||
| 出版社版DOI | ||||||||||||
| 関連識別子 | https://doi.org/10.1262/jrd.2021-025 | |||||||||||
| 関連名称 | 10.1262/jrd.2021-025 | |||||||||||
| 出版タイプ | ||||||||||||
| 出版タイプ | VoR | |||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||
| タイトル | ||||||||||||
| タイトル | Current status of the application of gene editing in pigs | |||||||||||
| タイトル別表記 | ||||||||||||
| その他のタイトル | GENE EDITING IN PIGS | |||||||||||
| 著者 |
谷原, 史倫
× 谷原, 史倫× 平田, 真樹× 音井, 威重
WEKO
772
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| 抄録 | ||||||||||||
| 内容記述 | Genetically modified animals, especially rodents, are widely used in biomedical research. However, non-rodent models are required for efficient translational medicine and preclinical studies. Owing to the similarity in the physiological traits of pigs and humans, genetically modified pigs may be a valuable resource for biomedical research. Somatic cell nuclear transfer (SCNT) using genetically modified somatic cells has been the primary method for the generation of genetically modified pigs. However, site-specific gene modification in porcine cells is inefficient and requires laborious and time-consuming processes. Recent improvements in gene-editing systems, such as zinc finger nucleases, transcription activator-like effector nucleases, and the clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein (CRISPR/Cas) system, represent major advances. The efficient introduction of site-specific modifications into cells via gene editors dramatically reduces the effort and time required to generate genetically modified pigs. Furthermore, gene editors enable direct gene modification during embryogenesis, bypassing the SCNT procedure. The application of gene editors has progressively expanded, and a range of strategies is now available for porcine gene engineering. This review provides an overview of approaches for the generation of genetically modified pigs using gene editors, and highlights the current trends, as well as the limitations, of gene editing in pigs. | |||||||||||
| キーワード | ||||||||||||
| 主題 | Clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein (CRISPR/Cas) | |||||||||||
| キーワード | ||||||||||||
| 主題 | Gene editing | |||||||||||
| キーワード | ||||||||||||
| 主題 | Pig | |||||||||||
| キーワード | ||||||||||||
| 主題 | Transcription activator-like effector nuclease (TALEN) | |||||||||||
| キーワード | ||||||||||||
| 主題 | Zinc finger nuclease (ZFN) | |||||||||||
| 書誌情報 |
en : Journal of Reproduction and Development 巻 67, 号 3, p. 177-187, 発行日 2021 |
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| 収録物ID | ||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||
| 収録物識別子 | 13484400 | |||||||||||
| 収録物ID | ||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||
| 収録物識別子 | 09168818 | |||||||||||
| 収録物ID | ||||||||||||
| 収録物識別子タイプ | NCID | |||||||||||
| 収録物識別子 | AA10936678 | |||||||||||
| 出版者 | ||||||||||||
| 出版者 | Society for Reproduction and Development | |||||||||||
| 権利情報 | ||||||||||||
| 権利情報 | This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: https://creativecommons.org/licenses/by-nc-nd/4.0/) | |||||||||||
| EID | ||||||||||||
| 識別子 | 378547 | |||||||||||
| 言語 | ||||||||||||
| 言語 | eng | |||||||||||
