| Item type |
文献 / Documents(1) |
| 公開日 |
2022-03-02 |
| アクセス権 |
|
|
アクセス権 |
open access |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.3390/toxins13070467 |
|
|
言語 |
ja |
|
|
関連名称 |
10.3390/toxins13070467 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Serodiagnosis and Bacterial Genome of Helicobacter pylori Infection |
|
言語 |
en |
| 著者 |
イチハラ, アイナ
オジマ, ヒナコ
ゴトウ, カズヨシ
マツシタ, オサム
タケ, ススム
オカダ, ヒロユキ
渡辺, 朱理
ヨコタ, ケンジ
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
The infection caused by Helicobacter pylori is associated with several diseases, including gastric cancer. Several methods for the diagnosis of H. pylori infection exist, including endoscopy, the urea breath test, and the fecal antigen test, which is the serum antibody titer test that is often used since it is a simple and highly sensitive test. In this context, this study aims to find the association between different antibody reactivities and the organization of bacterial genomes. Next-generation sequences were performed to determine the genome sequences of four strains of antigens with different reactivity. The search was performed on the common genes, with the homology analysis conducted using a genome ring and dot plot analysis. The two antigens of the highly reactive strains showed a high gene homology, and Western blots for CagA and VacA also showed high expression levels of proteins. In the poorly responsive antigen strains, it was found that the inversion occurred around the vacA gene in the genome. The structure of bacterial genomes might contribute to the poor reactivity exhibited by the antibodies of patients. In the future, an accurate serodiagnosis could be performed by using a strain with few gene mutations of the antigen used for the antibody titer test of H. pylori. |
|
言語 |
en |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
antibody |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
VacA |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
CagA |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
genome |
| 書誌情報 |
en : Toxins
巻 13,
号 7,
p. 467,
発行日 2021-07-05
|
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
20726651 |
| 出版者 |
|
|
出版者 |
MDPI |
|
言語 |
en |
| 権利情報 |
|
|
言語 |
en |
|
権利情報 |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
| EID |
|
|
識別子 |
377842 |
|
識別子タイプ |
URI |
| 言語 |
|
|
言語 |
eng |
toxins_13_7_467.pdf (3.1 MB)
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