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Specific impact of β5t on proteasome subunit composition in cortical thymic epithelial cells
https://tokushima-u.repo.nii.ac.jp/records/2009613
https://tokushima-u.repo.nii.ac.jp/records/200961377f7b4bb-d758-42e9-bedd-8d57909fcd4c
| 名前 / ファイル | ライセンス | アクション |
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celrep_36_10_109657.pdf (1.29 MB)
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| Item type | 文献 / Documents(1) | |||||||||||||||||
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| 公開日 | 2022-03-08 | |||||||||||||||||
| アクセス権 | ||||||||||||||||||
| アクセス権 | open access | |||||||||||||||||
| 資源タイプ | ||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||
| 出版社版DOI | ||||||||||||||||||
| 識別子タイプ | DOI | |||||||||||||||||
| 関連識別子 | https://doi.org/10.1016/j.celrep.2021.109657 | |||||||||||||||||
| 言語 | ja | |||||||||||||||||
| 関連名称 | 10.1016/j.celrep.2021.109657 | |||||||||||||||||
| 出版タイプ | ||||||||||||||||||
| 出版タイプ | VoR | |||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||
| タイトル | ||||||||||||||||||
| タイトル | Specific impact of β5t on proteasome subunit composition in cortical thymic epithelial cells | |||||||||||||||||
| 言語 | en | |||||||||||||||||
| 著者 |
大東, いずみ
× 大東, いずみ
WEKO
424
× 高浜, 洋介
WEKO
1519
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| 抄録 | ||||||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||||||
| 内容記述 | β5t is a cortical thymic epithelial cell (cTEC)-specific component of the thymoproteasome, which is essential for the optimal production of functionally competent CD8+ T cells. Our recent analysis showed a specific impact of β5t on proteasome subunit composition in cTECs, supporting the possibility that the thymoproteasome optimizes CD8+ T cell development through the production of MHC-I-associated unique self-peptides in cTECs. However, a recent article reports that β5t regulates the expression of hundreds of cTEC genes and affects both CD4+ and CD8+ thymocytes by causing oxidative stress in thymocytes. The authors further analyze our published data and describe that they confirm their conclusions. Here, we examine the issues that they raise and conclude that, rather than regulating hundreds of genes in cTECs, β5t has a highly specific impact in cTECs on proteasome subunit composition. | |||||||||||||||||
| 言語 | en | |||||||||||||||||
| 書誌情報 |
en : Cell Reports 巻 36, 号 10, p. 109657, 発行日 2021-09-07 |
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| 収録物識別子タイプ | ISSN | |||||||||||||||||
| 収録物識別子 | 22111247 | |||||||||||||||||
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| 出版者 | Elsevier | |||||||||||||||||
| 言語 | en | |||||||||||||||||
| 権利情報 | ||||||||||||||||||
| 言語 | en | |||||||||||||||||
| 権利情報 | This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). | |||||||||||||||||
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| 識別子 | 382607 | |||||||||||||||||
| 識別子タイプ | URI | |||||||||||||||||
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| 言語 | eng | |||||||||||||||||
